Antispasmodic effect of Mentha piperita essential oil on tracheal smooth muscle of rats |
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Authors: | Albertina Antonielly Sydney de Sousa Pedro Marcos Gomes Soares Arisa Nara Saldanha de Almeida Alana Rufino Maia Emmanuel Prata de Souza Ana Maria Sampaio Assreuy |
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Institution: | 1. Laboratório de Fisio-Farmacologia da Inflamação-LAFFIN, Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Av. Paranjana 1700, 60740-000 Fortaleza, CE, Brazil;2. Departamento de Morfologia, Universidade Federal do Ceará, Rua Delmiro de Farias S/N, Rodolfo Teófilo, 60.416-030 Fortaleza, CE, Brazil;3. Departamento de Biologia Molecular, Universidade Federal da Paraíba, Cidade Universitária, CEP 58059-900, João Pessoa, PB, Brazil |
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Abstract: | Aim of the studyMentha piperita is a plant popularly known in Brazil as “hortelã-pimenta” whose essential oil is used in folk medicine for its anti-inflammatory, antispasmodic, expectorant actions and anti-congestive. Here, it was investigated the effect of Mentha piperita essential oil (peppermint oil) in rat tracheal rings along with its mechanism of action.Materials and methodsTracheal tissue from Male Wistar rats (250–300 g) were used. Peppermint oil was added in cumulative concentrations 1–300 μg/ml] to the tissue basal tonus or pre-contracted by carbachol 10 μM] at 10 min intervals, incubated or not with indomethacin 10 μM], l-N-metyl-nitro-arginine 100 μM], hexamethonium 500 μM], or tetraethylammonium 5mM].ResultsPeppermint oil 100 and 300 μg/ml] inhibited the contractions induced by carbachol, which was reversed by indomethacin, l-N-metyl-nitro-arginine and hexamethonium, but not by tetraethylammonium. These data suggest the participation of prostaglandin E2, nitric oxide and autonomic ganglions in the peppermint oil relaxant effect and may be correlated with its popular use in respiratory diseases.ConclusionsPeppermint oil exhibited antispasmodic activity on rat trachea involving prostaglandins and nitric oxide synthase. |
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Keywords: | Essential oil Mentha piperita Trachea Smooth muscle Antispasmodic activity |
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