Analgesic and anti-inflammatory effects of Pistacia integerrima extracts in mice |
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Authors: | Naseem Saud Ahmad Akbar Waheed Muhammad Farman Aisha Qayyum |
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Affiliation: | 1. Department of Pharmacology, Wah Medical College Wah Cantt, University of Health Sciences, Lahore, Khayaban-e-Jamia Punjab, Lahore, Pakistan;2. Department of Pharmacology, Army Medical College, National University of Sciences and Technology, Islamabad, Pakistan;3. Department of Chemistry, Quaid-i- Azam University, Islamabad, Pakistan |
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Abstract: | Aim of studyExtracts of Pistacia integerrima galls have been dispensed by Traditional Practitioners of Subcontinent for chest diseases as well as for aches and pains in the body. This study was planned to evaluate the possible analgesic and antiinflammatory effects of Pistacia integerrima extracts.Materials and methodsAnalgesia was determined using acetic acid induced abdominal constriction and formalin induced paw licking in mice. Antinociceptive effect was observed by thermally induced algesia in mice.ResultsPistacia integerrima leaves extracts showed significant response against chemically induced pain (P < 0.001) whereas galls extracts had highly significant protection (P < 0.0001) in a dose dependent manner. In thermally induced algesia, Pistacia integerrima galls extracts 200 mg/kg (p.o.), showed significant (P < 0.05) response but less than pentazocine and diclofenac, positive references. The extracts of Pistacia integerrima 50–200 mg/kg (p.o.) had modest activity against hind paw acute and chronic inflammation induced by formalin (P < 0.01).ConclusionThese results demonstrate that Pistacia integerrima extracts have antinociceptive and analgesic effects and no apparent acute toxicity on oral administration. |
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Keywords: | CCl4, carbon tetrachloride COX, cyclooxygenase CT, reaction time for control EtOH, ethanol g, gram kg, kilogram ml, milliliter MPE, maximum possible effect NIH, National Institute of Health P., Pistacia p.o., per oral s.c., subcutaneous SEM, standard error of the means S&ndash N&ndash K test, Students&ndash Neuman&ndash Keuls test TT, reaction time for drug XO, xanthine oxidase Vc, value of control Vt, value of test compound |
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