Antimalarial compounds from the aerial parts of Flacourtia indica (Flacourtiaceae) |
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| Authors: | Ali Mohamed Kaou,Valé rie Mahiou-Leddet,Cé cile Canlet,Laurent Debrauwer,Sé bastien Hutter,Michè le Laget,Robert Faure,Nadine Azas,Evelyne Ollivier |
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| Affiliation: | 1. Laboratoire de Pharmacognosie et Ethnopharmacologie, UMR-MD3, Faculté de Pharmacie, Université de la Méditerranée (Aix-Marseille II), 27 Bd Jean Moulin, 13385 Marseille Cedex 5, France;2. Laboratoire des Xénobiotiques, INRA, UMR1089, 180 Chemin de Tournefeuille BP 93173, 31027 Toulouse Cedex 3, France;3. Laboratoire de Parasitologie, UMR-MD3, Faculté de Pharmacie, Université de la Méditerranée (Aix-Marseille II), 27 Bd Jean Moulin, 13385 Marseille Cedex 5, France;4. UMR ISM2, Université Paul Cézanne, Marseille, France |
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| Abstract: | Aim of the studyIn the Comoros Islands, the aerial parts of Flacourtia indica are used in traditional medicine to treat malaria. Because of the important use of this plant, the phytochemistry of the aerial parts was investigated.Materials and methodsThree compounds were isolated from the decoction of this plant material, Pyrocatechol, Homaloside D and Poliothrysoside. The in vitro antiplasmodial activity on the chloroquine-resistant strain (W2) of Plasmodium falciparum and the cytotoxicity on two complementary human cell lines (THP1, HepG2), of AcOEt extract obtained after liquid/liquid extraction of the decoction and pure compounds, were evaluated.ResultsThe Poliothrysoside isolated from the AcOEt extract presented a strong antiplasmodial activity (IC50 = 7.4 μM) and a good selectivity index (>28) similar to chloroquine.ConclusionThis study reports for the first time antiplasmodial activity for Flacourtia indica, for its AcOEt extract and the three major constituents and confirms its traditional use. |
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| Keywords: | Flacourtia indica Flacourtiaceae Comoros Traditional medicine Antiplasmodial activity Plasmodium falciparum |
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