Ameliorative and neuroprotective effect in MPTP model of Parkinson's disease by Zhen-Wu-Tang (ZWT), a traditional Chinese medicine |
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| Authors: | Xiu-Min Li Hai-Bin Ma Zhan-Qiang Ma Lu-Fan Li Chang-Liang Xu Rong Qu Shi-Ping Ma |
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| Affiliation: | 1. Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing 210009, PR China;2. Department of Pharmacology of Traditional Chinese Medical Formulae, Nanjing University of Traditional Chinese Medicine, Nanjing 210029, PR China |
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| Abstract: | Aim of the studyTraditional Chinese medicine Zhen-Wu-Tang (ZWT) is a well-known PentaHerbs formula from “Treatise on Febrile Disease”. This study is to elucidate its neuroprotective effect and mechanism of ameliorative effect of the syndrome of Parkinson's disease (PD).Materials and methodsThe ameliorative effect of ZWT on symptom of PD through behavior tests including: swimming test, the tail suspension test and open-field test was investigated. The neuroprotective effect of dopaminergic neurons from the striatum and frontal cortex of brain was detected by high performance liquid chromatography with electrochemical detection (HPLC-ECD).ResultsThis study proved that ZWT could ameliorate the typical symptom of PD and protect dopaminergic system.ConclusionThese results suggested that ZWT possessed protective and ameliorative properties of dopaminergic neurons. |
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| Keywords: | ZWT, Zhen-Wu-Tang PD, Parkinson's disease SN, substantia nigra HPLC-ECD, high performance liquid chromatography with electrochemical detection MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydrophyridine DA, dopamine DOPAC, 3,4-dihydroxyphenylacetic acid HVA, homovanillic acid 5-HT, serotonin 5-HIAA, 5-hydroxyindoleacetic acid VTA, ventral tegmental area DHBA, 3,4-dihydroxybenzylamine l-DOPA, l-3,4-dihydroxyphenylalanine SOD, superoxide dismutase MDA, malondialdehyde |
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