The association of V249I and T280M fractalkine receptor haplotypes with disease course of multiple sclerosis |
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| Authors: | Stojkovi? Ljiljana Djuri? Tamara Stankovi? Aleksandra Din?i? Evica Stan?i? Olja Veljkovi? Nevena Alavanti? Dragan Zivkovi? Maja |
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| Institution: | Laboratory for Radiobiology and Molecular Genetics, "Vin?a" Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia. |
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| Abstract: | We investigated the association of CX3CR1 genotypes/haplotypes with MS and performed the prediction analysis of protein sequence variants' effects on CX3CL1/CX3CR1 interaction. We found no association of CX3CR1 with MS susceptibility. Frequency of I(249)T(280) haplotype was significantly lower in SP compared to RR patients (RR>10 years, OR=0.30, 95%CI=0.11-0.79, p=0.01; OR=0.53, 95%CI=0.18-1.56, p=0.2, in SP<10 years vs. RR>10 years). Prediction analysis showed that I249 T280 protein variant would significantly affect CX3CL1/CX3CR1 interaction. Our results suggest that CX3CR1 I???T??? haplotype could have protective effect for switch to SP MS. Further research is warranted to validate and replicate currently observed results. |
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