The CD4+ T-cell subset lacking expression of the CD28 costimulatory molecule is expanded and shows a higher activation state in multiple sclerosis |
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Authors: | Pinto-Medel María Jesús García-León Juan Antonio Oliver-Martos Begoña López-Gómez Carlos Luque Gloria Arnáiz-Urrutia Carlos Orpez Teresa Marín-Bañasco Carmen Fernández Oscar Leyva Laura |
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Institution: | Research Laboratory, Hospital Regional Universitario Carlos Haya and Fundación IMABIS, Málaga, Spain. |
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Abstract: | Multiple sclerosis (MS) is a chronic debilitating disease, in which T-cells are considered to play a pivotal role. CD28 is the quintessential costimulatory molecule on T-cells and its expression declines progressively with repeated stimulations, leading to the generation of CD28(-) T-cells. Our aim was to examine whether CD4(+)CD28(-) T-cells were enriched in MS patients, and characterize the phenotype of this subset in MS patients and healthy controls (HC). All these changes could provide these CD4(+)CD28(-) T-cell characteristics that might be involved in the pathogenesis of MS, turning this T-cell subset into a potential target for future therapeutic strategies. |
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