八角莲治疗乙型脑炎的动物实验

应用八角莲治疗乙脑患者,具有缩短疗程和降低病死率作用。为证实八角莲对乙脑的治疗作用,作小鼠实验研究。结果表明:1,八角莲治疗组的小鼠生存曲线明显高于对照组(X~2=5.484 P<0.05);2,八角莲组病死率为63%(38/60)较对照组病死率95%(19/20)有显著差别(X~2=6.24 P<0.05);3.病理检查结果表明对照组(病毒+生理盐水)有脑实质和脑膜血管充血、淋巴套、胶质小体、软化灶形成等典型乙脑病变,而八角莲治疗组病变明显减轻,仅是神经原变性,嗜神经现象。作者认为八角莲的治疗作用可能是:1,抗病毒作用,使乙脑病毒的复制受到抑制;2,增强抗体的细胞免疫功能而促使乙脑康复。

An Experimental Study on the Treatment of Murine Eneeohalitis B with Ba-jian-Lian Injection

The clinical effects of Ba-Jian-Lian (Dysosma pleiantha) had been described in Chinese traditional medicine, It has antipyretic, expectorant and detumescent effects. Pharmaceutic studies showed that it contains podophyllotoxin with anti-cancer effect. Clinical studies showed that the Ba-Jian-Lian is capable of shortening the course and decreasing the case fatality in patients with encephalitis B. The results of experiment in mice indicated: 1. The survival curve in the Ba-Jian-Lian group was significantly higher than that in the control group; 2. The fatality in Ba-Jian-Lian treated group ( 63%, 38/60) was lower than that in the control group (95%,19/20) (x~2=6.24,P<0.05); 3. The peri-vascular cuffing, petechial hemorrhages microglial proliferation and focal necrosis as the typical pathologic features of encephalitis appeared in brain and meninges of the control group. The pathological changes were much alleviated in the treated group, only neuronophagia was observed in Ba-Jian-Lian group. Its therapeutic effect might be anti-viral by suppressing the replication of the virus or through enhancing the cellular immuning.