| 非HLA基因多态性与异基因造血干细胞移植后并发症发生 |
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| 引用本文： | 吴小津,吴德沛.非HLA基因多态性与异基因造血干细胞移植后并发症发生[J].中华移植杂志（电子版）,2010,4(1):50-54. |
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| 作者姓名： | 吴小津 吴德沛 |
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| 作者单位： | 苏州大学附属第一医院血液科,215006 |
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| 基金项目： | 江苏省领军人才资助项目(200626); 苏州大学优秀博士课题资助项目(23320928) |
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| 摘 要： | 越来越多的研究表明,非HLA的基因多态性可能在预测异基因造血干细胞移植后移植物抗宿主病、生存和感染等方面有着重要意义。本综述总结了IL-1基因家族、IL-2基因家族、IL-6基因、IL-10基因、TGF-β基因、TNF基因、维生素D受体基因、髓过氧化物酶基因、Fcγ受体基因、甘露糖结合凝集素基因、NOD2/CARD15基因、MTHFR基因、P2X7基因、HFE基因等基因多态性与造血干细胞移植相关性的最新研究结果 。
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| 关 键 词： | 异基因造血干细胞移植 非HLA基因 多态性 并发症 |
The association studies between non-HLA gene polymorphisms and the complications after allogenetic hematopoietic stem cell transplantation |
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| WU Xiao-jin,WU De-pei.The association studies between non-HLA gene polymorphisms and the complications after allogenetic hematopoietic stem cell transplantation[J].Chinese Journal of Transplanation(Electronic Version),2010,4(1):50-54. |
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| Authors: | WU Xiao-jin WU De-pei |
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| Institution: | WU Xiao-jin,WU De-pei. Department of Hematology,the First Affiliated Hospital of Soochow University,Suzhou 215006,China |
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| Abstract: | Accumulating evidences have shown that non-HLA gene polymorphisms may play an important role in predicting outcomes including graft-versus-host disease, survivals and infections in allo- genetic hematopoietic stem cell transplantation. This article summarized the latest studies on non-HLA gene polymorphisms（including IL-1 family, IL-2 family, IL-6, IL-10, TGF-13, TNF, vitamin D receptor, myeloperoxidase, Fc gamma receptor, mannose-binding lectin, NOD2/CARD15, MTHFR, P2X7, and HFE）and transplant outcomes. |
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| Keywords: | Allogeneic hematopoietic stem cell transplantation Non-HLA gene Polymorphisms Complications |
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