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肝移植后脑病围手术期危险因素分析
引用本文:孙海云,蔡珺,关健强,罗刚健,黑子清,黎尚荣. 肝移植后脑病围手术期危险因素分析[J]. 中华移植杂志(电子版), 2010, 4(1): 19-22. DOI: 10.3877/cma.j.issn.1674-3903.2010.01.006
作者姓名:孙海云  蔡珺  关健强  罗刚健  黑子清  黎尚荣
作者单位:中山大学附属第三医院麻醉科,广州,510630
基金项目:广东省科技计划资助项目(2006B36003019)
摘    要:目的分析肝移植术后脑病发生的危险因素,为预防提供思路。方法观察并追踪240例肝移植受者,统计分析不同原发病、Child-Turcotte-Pugh(CTP)分级、终末期肝病模型(MELD)评分患者术后脑病的发生率,并根据脑病发生与否分为脑病组和非脑病组,分析两组间术前、术中及术后相关因素的差异。结果 240例肝移植患者中57例(23.7%)术后出现了脑病症状,其中表现为焦虑不安27例、谵妄13例、妄想8例、抽搐7例、听觉障碍2例。Logistic回归分析结果显示术前凝血酶原时间18s和术后血肌酐浓度大于正常参考值是肝移植术后脑病发生的主要危险因素。结论肝移植后脑病的发生与多种因素有关,其中术前凝血酶原时间在18s以上和术后血肌酐浓度大于正常参考值是最重要的危险因素。

关 键 词:肝移植  脑病  并发症  围手术期  危险因素

The analysis of perioperative risk factors for the incidence of encephalopathy after orthotopic liver transplantation
SUN Hai-yun,CAI Jun,GUAN Jian-qiang,LUO Gang-jian,HEI Zi-qing,LI Shang-rong. The analysis of perioperative risk factors for the incidence of encephalopathy after orthotopic liver transplantation[J]. Chinese Journal of Transplanation(Electronic Version), 2010, 4(1): 19-22. DOI: 10.3877/cma.j.issn.1674-3903.2010.01.006
Authors:SUN Hai-yun  CAI Jun  GUAN Jian-qiang  LUO Gang-jian  HEI Zi-qing  LI Shang-rong
Affiliation:SUN Hai-yun,CAI Jun,GUAN Jian-qiang,LUO Gang-jian,HEI Zi-qing,LI Shang-rong. Department of Anesthesiology,the Third Affiliated Hospital,Sun Yat-sen University,Guangzhou 510630,China
Abstract:Objective To determine the incidence and identify the risk factors of encephalopathy after orthotopic liver transplantation( OLT) . Methods The incidence of encephalopathy after OLT in 240 patients with different hepatic diseases,Child-Turcotte-Pugh ( CTP) classes,and the model for endstage liver disease ( MELD) scores undergoing OLT was analyzed. The patients were then divided into 2 groups: encephalopathy group and non-encephalopathy group,and the risk factors were determined by correlation analysis and l...
Keywords:Liver transplantation  Encephalopathy  Complications  Perioperation  Risk factors  
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