| 基质金属蛋白酶-12及其组织抑制物-1在皮肤鳞状细胞癌中的表达及意义 |
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| 引用本文： | 宣敏,杨慧兰,樊建勇,梁洁,张玲. 基质金属蛋白酶-12及其组织抑制物-1在皮肤鳞状细胞癌中的表达及意义[J]. 中国美容医学, 2011, 20(2): 237-239 |
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| 作者姓名： | 宣敏 杨慧兰 樊建勇 梁洁 张玲 |
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| 作者单位： | 1. 广州军区广州总医院皮肤科,广东,广州,510010;南方医科大学研究生院,广东,广州,510015
2. 广州军区广州总医院皮肤科,广东,广州,510010 |
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| 摘 要： | 目的：检测基质金属蛋白酶-12（MMP-12）及其组织抑制物-1（TIMP-1）在皮肤鳞状细胞癌（SCC）中的表达并探讨其与肿瘤分化、淋巴转移的关系。方法：免疫组化法检测MMP-12及TIMP-1在20例正常皮肤组织和32例鲍温病（BD）、53例SCC患者皮损中的表达。结果：在正常人皮肤和BD患者皮损中,MMP-12不表达,TIMP-1呈弱阳性表达,而两者在皮肤SCC患者皮损中均呈弥漫表达,MMP-12在SCC患者瘤组织中表达阳性率为92.4%,在低分化组或有淋巴结转移组中的表达明显高于高分化组（P=0.009）或无淋巴结转移组（P=0.01）;TIMP-1在SCC患者皮损中表达阳性率为84.9%,在高分化组或无淋巴结转移组中的表达明显高于低分化组（P=0.005）或有淋巴结转移组（P=0.01）。结论：MMP-12、TIMP-1蛋白的表达可能与SCC的癌分化和转移有关,MMP-12高表达与TIMP-1低表达提示SCC肿瘤细胞可能有较高的侵袭潜能。
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| 关 键 词： | 鳞状细胞癌 Bowen病 巨噬细胞金属弹力酶 金属蛋白酶类组织抑制剂 |
Expression of matrix metalloproteinase-12 and its tissue inhibitor-1 in cutaneous squamous cell carcinoma |
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| XUAN Min,YANG Hui-lan,FAN Jian-yong,LIANG Jie,ZHANG Ling. Expression of matrix metalloproteinase-12 and its tissue inhibitor-1 in cutaneous squamous cell carcinoma[J]. Chinese Journal of Aesthetic Medicine, 2011, 20(2): 237-239 |
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| Authors: | XUAN Min YANG Hui-lan FAN Jian-yong LIANG Jie ZHANG Ling |
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| Affiliation: | XUAN Min1,2,YANG Hui-lan1,FAN Jian-yong1,LIANG Jie1,ZHANG Ling1(1.Department of Dermotology,Guangzhou General Hospital of Guangzhou Military Command,Guangzhou 510010,Guangdong,China,2.Graduate School of Nanfang Medical University,Guangzhou 510015,China) |
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| Abstract: | Objective To investigate the expression of matrix metalloproteinase-12(MMP-12)and its tissue inhibitor-1(TIMP-1)in cutaneous squamous cell carcinoma(SCC)and the relationship between the expression and tumor differentiation and lymph node metastasis.Methods Immunohistochemical method was used to detect the expression of MMP-12 and TIMP-1 proteins on the paraffin embedded sections of 53 patients with SCC and 32 patients with BD.Results MMP-12 and TIMP-1 proteins were diffusely expressed in the tumor nets and ... |
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| Keywords: | squamous cell carcinoma bowen's disease macrophage metalloelastase tissue inhibitor of metalloproteinase |
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