Amplification of HER2 is a marker for global genomic instability |
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| Authors: | Rachel E Ellsworth Darrell L Ellsworth Heather L Patney Brenda Deyarmin Brad Love Jeffrey A Hooke Craig D Shriver |
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| Affiliation: | (1) Clinical Breast Care Project, Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, MD, USA;(2) Clinical Breast Care Project, Windber Research Institute, Windber, PA, USA;(3) Invitrogen, Carlsbad, CA, USA;(4) Clinical Breast Care Project, Walter Reed Army Medical Center, Washington, DC, USA |
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| Abstract: | Background Genomic alterations of the proto-oncogene c-erbB-2 (HER-2/neu) are associated with aggressive behavior and poor prognosis in patients with breast cancer. The variable clinical outcomes seen in patients with similar HER2 status, given similar treatments, suggests that the effects of amplification of HER2 can be influenced by other genetic changes. To assess the broader genomic implications of structural changes at the HER2 locus, we investigated relationships between genomic instability and HER2 status in patients with invasive breast cancer. |
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