| 环孢菌素A对儿童过敏性紫癜T细胞功能状态的干预作用 |
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| 引用本文： | 李秋,杨锡强,李永柏,王莉佳.环孢菌素A对儿童过敏性紫癜T细胞功能状态的干预作用[J].中国实用儿科杂志,2001,16(10):604-606. |
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| 作者姓名： | 李秋 杨锡强 李永柏 王莉佳 |
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| 作者单位： | 重庆医科大学附属儿童医院 |
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| 摘 要： | 目的观察环孢菌素A(CsA)对儿童过敏性紫癜(HSP)T细胞功能状态的干预作用.方法采用流式细胞技术及ELISA法检测PBMC细胞膜上CD40L表达及PBMC培养上清中细胞因子水平.结果CsA在体外具有纠正HSP患儿PBMC异常表达CD40L的作用(P＜0.05),并抑制TH2类细胞因子(IL-4、IL-5、IL6)的过度产生,使TH1类细胞因子(IL-2、IFN-γ)的释放进一步减少(P＜0.05).结论CsA具有显著抑制HSP患儿T细胞功能作用,尤其是对T细胞亚群(TH1)细胞的功能抑制更强.
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| 关 键 词： | 环孢菌素A 紫癜 过敏性 T淋巴细胞 |
| 文章编号： | 1005-2224(2001)10-0604-03 |
| 修稿时间： | 2001年2月15日 |
Role of cyclosporin A in T - cell' s function state of children with Henoch - Schonlein purpura |
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| Li Qiu,Yang Xiqiang,Li Yongbai,et al\ \ Children's Hospital,Chongqing University of Medical Sciences,Chongqing.Role of cyclosporin A in T - cell'''' s function state of children with Henoch - Schonlein purpura[J].Chinese Journal of Practical Pediatrics,2001,16(10):604-606. |
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| Authors: | Li Qiu Yang Xiqiang Li Yongbai \ \ Children's Hospital Chongqing University of Medical Sciences Chongqing |
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| Institution: | Li Qiu,Yang Xiqiang,Li Yongbai,et al\ \ Children's Hospital,Chongqing University of Medical Sciences,Chongqing 400014 |
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| Abstract: | Objective\ To investigate the roles of cyclosporin A(CsA)in T-cells of Henoch-Schonlein purpura(HSP)patients.Methods\ CD40L expression on peripheral blood mononuclear cells(PBMC)were analyzed by flow cytometry(FACS).Cytokines level in the supernatants of cultured PBMC were detected by ELISA.Results\ Huyperexpression of CD40L and the enhanced T H2 cytokines such as IL 4,IL 5 and IL 6 could be affected by CsA in vitro.The T H1 cytokines were furtherly inhibited.Conclusion\ CsA can significantly inhibit T-cell's function,especially T H1 function. |
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| Keywords: | Cyclosporin A\ Henoch-Schonlein purpura\ T-cell |
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