Serum levels of tissue inhibitor of metalloproteinase-1 and periarticular bone loss in early rheumatoid arthritis |
| |
Authors: | Eithne Murphy Pascale Roux-Lombard Terence Rooney Oliver FitzGerald Jean-Michel Dayer Barry Bresnihan |
| |
Institution: | (1) Department of Rheumatology, St Vincents University Hospital, Dublin, Ireland;(2) Division of Immunology and Allergy, University Hospital, Geneva, Switzerland |
| |
Abstract: | We investigated the relationship between disease activity, serum biological mediators of joint damage, and periarticular bone
loss in inflammatory arthritis. Patients with early inflammatory arthritis were recruited from a dedicated early arthritis
clinic. At the time of recruitment, all had clinical evidence of synovitis. Patients were assessed at baseline and at 1-year
follow-up. Periarticular and axial bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry. Serum levels
of matrix metalloproteinase 1 and tissue inhibitor of metalloproteinases 1 (TIMP-1) were measured by enzyme-linked immunosorbent
assay. A total 38 patients were included in the study. Twenty had rheumatoid arthritis (RA) and 18 had a seronegative spondylarthropathy
(SpA). At baseline, periarticular hand BMD measurements were similar in RA and SpA. At 1 year, the mean periarticular hand
BMD was significantly lower in RA (p < 0.05). Significant inverse correlations between both the Ritchie articular index and C-reactive protein levels and the
change in periarticular hand BMD at 1 year were observed in RA (r = −0.792, p < 0.001 and r = −0.478, p = 0.045, respectively). Baseline TIMP-1 levels correlated with the change in periarticular hand BMD at 1 year in RA (r = 0.519, p = 0.02). At 1 year, radiographic measures of joint damage were highest in RA. Inverse correlations between the change in
periarticular hand BMD and the changes in erosion score (r = −0.90, p = 0.04) were observed in patients demonstrating significant periarticular bone loss. Persistent disease activity was associated
with increased periarticular bone loss in the hands in patients with RA, consistent with synovitis-mediated periarticular
bone loss. The correlation between baseline TIMP-1 levels and periarticular bone loss over 1 year suggests that TIMP-1 may
have utility as a biomarker of periarticular bone loss in early RA. |
| |
Keywords: | Bone loss Rheumatoid arthritis TIMP-1 |
本文献已被 SpringerLink 等数据库收录! |
|