清眩调压方治疗更年期女性高血压病的临床研究

目的 探讨清眩调压方对更年期女性高血压病的降压效果及作用机理。

Clinical Study on Effect of Qingxuan Tiaoya Recipe in Treating Menopausal Women with Hypertension

Objective To investigate the effect and mechanism of Qingxuan Tiaoya Recipe （QXTYR） on depressing blood pressure in menopausal women with hypertension. Methods Patients were randomly assigned to two groups, the 44 patients in the test group were administered with perindopril tablet and QXTYR granule, while the 43 in the control group were administered with the same program, but a simulator of QXTYR was used to replace for the real one. The treatment course for them all was 2 months. Before and after treatment, the ambulatory blood pressure （ABMP）, heart rate, related clinical symptoms, blood lipids, serum estrodiol （E2 ）, high-sensitivity C-reactive protein （ Hs-CRP）, homocysteine （HCY） and angiotensin Ⅱ （ Ang Ⅱ ） were measured. Results The treatment in the test group showed an effect better than that in the control group in terms of reducing blood pressure variability and night-time blood pressure decrease rate （P 〈0.05）, with the total effective rate and markedly effective rate in lowering blood pressure superior to the control group （ P 〈0.05）, alleviating symptoms as headache, soreness and weakness of the waist and knees, and insomnia （ P 〈0.05）, and decreasing levels of heart rate, total cholesterol （TC）, low-density lipoprotein cholesterol （LDL-C）, Hs-CRP and Ang Ⅱ （ P 〈 0.05）, The plasma level of endogenous E2 was elevated after treatment in the test group （ P 〈 0.05）, but showed no statistical difference in the control group. Conclusions QXTYR shows favorable effect in depressing blood pressure of menopausal women with hypertension, it can reduce blood pressure variability, improve the symptoms of the menopause syndrome, blood lipid metabolism and plasma levels of Hs-CRP, E2, and AngⅡ in patients, suggesting that its mechanism may be related to the functional regulation of sympathetic-vagus nerve and neuro-endocroimmune system, and also the inhibition on the circulatory renin-angiotensin-aldosterone system activity.