| 矽宁在家兔体内的药代动力学 |
| |
| 引用本文： | 秦黎辉,程玉海,徐旭,黄如衡. 矽宁在家兔体内的药代动力学[J]. 卫生研究, 1991, 0(5) |
| |
| 作者姓名： | 秦黎辉 程玉海 徐旭 黄如衡 |
| |
| 作者单位： | 中国预防医学科学院劳动卫生与职业病研究所，中国预防医学科学院劳动卫生与职业病研究所，军事医学科学院毒物药物所，军事医学科学院毒物药物所 |
| |
| 摘 要： | 利用磷光分析法研究了矽宁在家兔体内的药代动力学、生物利用度及血浆蛋白结合率。该法测定生物样品中矽宁含量的灵敏度可达5ng,变异系数为5.57％,平均回收率为83±2％。家兔口服或静注矽宁后,血药浓度-时间的动力学过程符合二室开放式模型。口服给药达峰时间为7.20分钟,表观分布容积较大,组织分布广泛。口服给药的绝对生物利用度为93％。矽宁与小鼠血浆蛋白的结合率为75±2％。
|
| 关 键 词： | 矽宁 磷光分析法 药代动力学 |
The Pharmacokinetics of Xinin in Rabbits |
| |
| Qin Lihui et al.. The Pharmacokinetics of Xinin in Rabbits[J]. Journal of hygiene research, 1991, 0(5) |
| |
| Authors: | Qin Lihui et al. |
| |
| Abstract: | Xinin is an analogue of Tilorone. It possesses significant curative effect on the experimental silicosis in rats. A Phosphorescent method for the determination of Xinin was developed Studies on the pharmacokinetics and bioavailability of Xinin after oral and iv. administration were carried out in rabbits. The blood drug concentration-time curve was found to fit a two compartment model with the following pharmacokinetic parameters: T 1/2α=6.44min,T1/2β=60.74min, Tmax = 7.2min, Vb=4.91L/kg and Cl=67.95ml/kg.min. The plasma binding rate in mice was 75+2%. The bioavailability of Xinin was 93% after oral administration of Xinin in dose of 20mg/kg to rabbits. |
| |
| Keywords: | Xinin phosphorescent method pharmacokinetics |
| 本文献已被 CNKI 等数据库收录！ |
|
