Aggressive CD34-positive Fibrous Scalp Lesion of Childhood: Extrapulmonary Solitary Fibrous Tumor |
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Authors: | PK Ramdial A Madaree |
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Institution: | (1) Department of Pathology, Faculty of Medicine, University of Natal, Private Bag 7, Congella, 4013, South Africa, ZA;(2) Department of Plastic and Reconstructive Surgery, Faculty of Medicine, University of Natal, Private Bag 7, Congella, 4013, Kwazulu Natal, South Africa, ZA |
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Abstract: | Although solitary fibrous tumor (SFT) was originally described as a pleural tumor, an increasing number of extrapleural sites
of SFTs have been documented. This has been attributed not only to the heightened awareness of the spectrum of histopathological
features that characterizes SFTs but also to the recognition of the role of CD34 immunostaining in soft tissue tumors in general,
and in SFTs in particular. Despite the large number of documented extrapleural SFTs in adults, cranial SFTs are rare, having
been documented in the meninges, scalp, and infratemporal fossa. Extrapleural SFTs are, to date, an unrecognized entity in
children.
We document an aggressive fibrous scalp lesion in a 30-month-old female child that demonstrated features common to benign
cranial fasciitis and SFT. However, based on bright, diffuse CD34 antigen immunopositivity, a diagnosis of SFT was made. The
need to include the CD34 antigen stain in a panel of immunohistochemical markers used to assess spindle cell lesions of childhood
is emphasized.
Received March 29, 1999; accepted February 28, 2000. |
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Keywords: | : cranial childhood malignant solitary fibrous tumor CD-34 antigen |
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