广西北海涠洲岛陵水山海绵Mycale lingshuiensis的化学成分研究

目的 对采自中国广西北海涠洲岛海域的陵水山海绵Mycale lingshuiensis 的化学成分进行研究。方法 采用薄层层析、硅胶柱层析、凝胶柱色谱等分离手段，通过核磁共振等现代波谱技术以及铜靶单晶X-衍射分析，并结合文献数据，对陵水山海绵M. lingshuiensis中的化学成分进行分离和结构鉴定。结果 从陵水山海绵M. lingshuiensis中共分离鉴定了5个含氮化合物，包括4个单吲哚生物碱：3-吲哚甲醛（1），3-吲哚甲酸（2），3-（hydroxylacetyl）-indole（3），4-hydroxy-5-（indole-3-yl）-5-oxo-pentan-2-one（4）和1个核苷：胸苷（5）。结论 化合物1~5均为首次从该种海绵中分离得到。

Studies on the chemical constitutions of sponge Mycale lingshuiensis from the North China Sea

Objective To study the chemical constitutions of sponge Mycale lingshuiensis. Methods The isolation and purification of these compounds were performed via repeated TLC, silica gel column, and Sephadex LH-20 column chromatography. The structures of these compounds were identified by means of spectroscopic methods, X-ray diffraction analysis, and comparison with the data of literatures. Results Five known nitrogenous compounds including four monoindole alkaloids and a nucleoside were isolated from the sponge M. lingshuiensis and their structures were identified as indole-3-carboxaldehyde (1), 3-indolecarboxylic acid (2), 3-(hydroxylacetyl)-indole (3), 4-hydroxy-5-(indole-3-yl)-5-oxo-pentan-2-one (4), and thymidine (5). Conclusions Compounds 1~5 were discovered from the M. lingshuiensis for the first time.