介绍几种诱发性糖尿病动物模型

目的：综述诱发性糖尿病动物模型。方法：主要对诱发性糖尿病动物模型的制备方法、机理进行综述，并评价各自的优缺点。结果：诱发性糖尿病动物模型可分为化学试剂诱发模型、转基因模型、基因敲除模型等。结论：诱发性糖尿病动物模型的制备方法很多，各有其特点。糖尿病动物模型研究的不断进展，为深入探讨糖尿病病因、病机及其药物治疗提供了借鉴。

Introduction of Several Methods to Establish the Induced Animal Models of Diabetes Mellitus

Objective:To introduce some methods of producing the induced animal models of diabetes mellitus.Methods:The preparation methods and mechanism for the induced animal models of diabetes mellitus are summarized.The advantage and disadvantage of each method are reviewed respectively.Results:The induced animal models of diabetes mellitus currently available could mainly be divided into three categories:chemicla reagent induced model,transgenic model,gene knock-out model,etc.Conclusion:There are many methods in establishing the induced animal models of diabetes mellitus with their own characters individually.The research progress on animal models of diabetes mellitus might facilitate the further exploration on the etiology,pathogenesis and drug therapy of diabetes mellitus.