Serotonin transporter gene polymorphisms and treatment-resistant depression |
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| Authors: | Cristian Bonvicini Alessandra Minelli Catia Scassellati Marco Bortolomasi Matilde Segala Riccardo Sartori Mario Giacopuzzi Massimo Gennarelli |
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| Affiliation: | 1. Genetic Unit, I.R.C.C.S. “San Giovanni di Dio”, Fatebenefratelli, Brescia, Italy;2. Psychiatric Hospital “Villa Santa Chiara”, Verona, Italy;3. Department of Psychology and Cultural Anthropology, University of Verona, Verona, Italy;4. Department of Biomedical Sciences and Biotechnologies, Biology and Genetic Division, Brescia University School of Medicine, Brescia, Italy |
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| Abstract: | Major Depression Disorder (MDD) is a serious mental illness that is one of the most disabling diseases worldwide. In addition, approximately 15% of depression patients are defined treatment-resistant (TRD). Preclinical and genetic studies show that serotonin modulation dysfunction exists in patients with TRD. Some polymorphisms in the promoter region of the serotonin transporter gene (SLC6A4) are likely to be involved in the pathogenesis/treatment of MDD; however, no data are available concerning TRD. |
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| Keywords: | 5-HTTLPR, serotonin-transporter-linked promoter region, (43bp Ins=L allele/Del=S allele) ANOVA, analysis of variance ATD, acute tryptophan depletion DSM-IV, Diagnostic and Statistical Manual of Mental Disorders ECT, Electroconvulsive therapy HWE, Hardy-Weinberg Equilibrium M.I.N.I., Mini International Neuropsychiatric Interview M.M.S.E., Mini Mental State Examination MAF, minor Allele Frequency MDD, major depressive disorder PCR, polymerase chain reaction rMDD, remitted major depressive disorder rTMS, repetitive transcranial magnetic stimulation SLC6A4, serotonin transporter gene SNP, single nucleotide polymorphism SSRI, Selective Serotonin Reuptake Inhibitor STin2, 17-bp variable tandem repeat intron 2 TCA, trcyclic antidepressant TD, tryptophan depletion TRD, treatment-resistant depression |
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