Gastric dysmotility in healthy first-degree relatives of patients with schizophrenia |
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| Authors: | Sandy Berger,Michael Hocke,Karl-Jü rgen Bä r |
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| Affiliation: | 1. Department of Psychiatry and Psychotherapy, University Hospital, Philosophenweg 3, 07743 Jena, Germany;2. Department of Medicine, Gastrointestinal Unit, University Hospital, Jena, Germany |
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| Abstract: | Gastric dysmotility has been reported in patients suffering from major depression or schizophrenia. An increased sympathetic activity modulating the gastric pacemaker located in the antrum of the stomach has been suggested as the underlying pathology. Similar to patients suffering from schizophrenia, their first-degree relatives showed alterations in cardiac autonomic modulation. Here we aimed to investigate gastric myoelectrical activity in healthy relatives of patients suffering from paranoid schizophrenia. |
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| Keywords: | ANOVA, Analysis of variance ANS, Autonomic nervous system DSM IV, Diagnostic and Statistical Manual of mental disorders, 4th edition EGG, Electrogastrography FPI, Freiburger Persö nlichkeitsinventar GMA, Gastric myoelectrical activity HRV, Heart rate variability ICDF, Instability coefficient of dominant frequency ICDP, Instability coefficient of dominant power MANOVA, Multivariate analysis of variance PANSS, Positive and Negative Syndrome Scale SCID II, Structured Clinical Interview II |
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