Influence of chrysin on hepatic marker enzymes and lipid profile against d-galactosamine-induced hepatotoxicity rats |
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Authors: | Ganesan Pushpavalli Chinnadurai VeeramaniKodukkur Viswanathan Pugalendi |
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Institution: | Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamilnadu 608 002, India |
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Abstract: | Chrysin is a flavonoid that exists in nature and is the major component of some traditional medicinal herbs. We investigated the hepatoprotective and antihyperlipidaemic potential of chrysin against d-galactosamine (a single intraperitoneal injection 400 mg/kg BW) induced hepatotoxicity in male albino Wistar rats. d-GalN rats exhibited an increased hepato and nephro toxicity marker activities aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and gamma glutamyl transpeptidase and total bilirubin level while urea, uric acid and creatinine and lipid profile. It also negatively affected the serum total protein, albumin and A/G ratio. Rats treated with chrysin at different concentrations (25, 50 and 100 mg/kg BW) caused a significant improvement in serum protein level, decreased hepato and nephro toxicity markers. It also decreased the levels of very low density lipoprotein cholesterol and low density lipoprotein cholesterol while high density lipoprotein cholesterol significantly increased. It also decreased the levels of total cholesterol, phospholipids, triglycerides, free fatty acids in the plasma and tissues of liver and kidney. The effect of chrysin (25 mg/kg) is comparable with silymarin, a known hepatoprotective drug. Chrysin thus exhibits hepatoprotective and antihyperlipidaemic activity. |
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Keywords: | AST aspartate aminotransferase ALT alanine aminotransferase ALP alkaline phosphatase GGT gamma glutamyl transpeptidase d-GalN d-galactosamine DMSO dimethylsulfoxide VLDL-C very low density lipoprotein cholesterol LDL-C low density lipoprotein cholesterol HDL-C high density lipoprotein cholesterol TC total cholesterol TG triglycerides FFA free fatty acids PL phospholipids DMRT Duncan&rsquo s multiple range test IU International unit mg milligram |
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