Serum IL-7 and G-CSF in major depressive disorder |
| |
Authors: | Soili M. Lehto,Anne Huotari,Leo Niskanen,Karl-Heinz Herzig,Tommi Tolmunen,Heimo Viinamä ki,Heli Koivumaa-Honkanen,Kirsi Honkalampi,Sanna Sinikallio,Heli Ruotsalainen,Jukka Hintikka |
| |
Affiliation: | 1. Department of Psychiatry, Kuopio University Hospital and University of Eastern Finland, 70210 Kuopio, Finland;2. Department of Pharmaceutics, University of Kuopio, Finland;3. Institute of Biomedicine, Division of Physiology and Biocenter Oulu, University of Oulu, Finland;4. Department of Medicine, Kuopio University Hospital and University of Eastern Finland, 70210 Kuopio, Finland;5. Department of Clinical Medicine, University of Oulu, Finland;6. Department of Psychiatry, Lapland Hospital District, 97140 Rovaniemi, Finland;g Kuopio Psychiatric Center, P.O. Box 1777, 70211 Kuopio, Finland;h Department of Rehabilitation, Kuopio University Hospital, Kuopio, Finland |
| |
Abstract: | Major depressive disorder (MDD) has been associated with dysregulated immune systems and impaired T cell function, but data on depression-related alterations in the levels of immunomodulatory growth factors are scarce. In order to further clarify the mechanisms underlying immune system dysregulation in depressed subjects, we examined the associations between MDD and serum levels of two immunomodulatory growth factors, interleukin (IL)-7 and granulocyte-colony stimulating factor (G-CSF), in 122 subjects (MDD with long-term symptomatology, n = 61; controls, n = 61). The MDD subjects had lowered levels of IL-7. In a model adjusted for age, gender and body mass index, subjects in the lowest tertile of IL-7 had a 3.4-fold increased likelihood for MDD (p = 0.010). Further adjustments for sleep disturbances, alcohol use, smoking, and metabolic syndrome did not alter these findings. Moreover, the exclusion of subjects with rheumatoid arthritis, coronary heart disease, or the use of non-steroidal anti-inflammatory medications or oral corticosteroids only slightly attenuated the findings. The G-CSF levels did not differ between the two groups. The lowering of the serum levels of IL-7, a regulator of T cell homeostasis, in MDD subjects may underlie the depression-related impaired T cell function. |
| |
Keywords: | ADS, atypical depression supplement BDI, Beck Depression Inventory BMI, body mass index CNS, central nervous system CRP, C-reactive protein ELISA, enzyme-linked immunosorbant assay G-CSF, granulocyte-colony stimulating factor GM-CSF, granulocyte-macrophage colony stimulating factor HAM-D, Hamilton depression rating scale HDL-C, high-density lipoprotein cholesterol HMS, high mental symptom group IL, interleukin KUDEP, Kuopio Depression Study LDL-C, low-density lipoprotein cholesterol LMS, low mental symptom group LS, Life Satisfaction MDD, major depressive disorder MetS, metabolic syndrome NSAID, non-steroidal anti-inflammatory drug SCID, Structured Clinical Interview for DSM-IV TAS, Toronto Alexithymia Scale TC, total cholesterol TG, triglycerides Th cells, T helper cells. |
本文献已被 ScienceDirect 等数据库收录! |
|