Facial emotion perception in Chinese patients with schizophrenia and non-psychotic first-degree relatives |
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| Authors: | Huijie Li Raymond CK Chan Qing Zhao Xiaohong Hong Qi-yong Gong |
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| Institution: | 1. Neuropsychology and Applied Cognitive Neuroscience Laboratory, Institute of Psychology, Chinese Academy of Sciences, Beijing, China;2. Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China;3. Graduate School, Chinese Academy of Sciences, Beijing, China;4. Mental Health Centre, Medical College of Shantou University, Shantou, China;5. Huaxi MR Research Centre, Department of Radiology, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, China |
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| Abstract: | Although there is a consensus that patients with schizophrenia have certain deficits in perceiving and expressing facial emotions, previous studies of facial emotion perception in schizophrenia do not present consistent results. The objective of this study was to explore facial emotion perception deficits in Chinese patients with schizophrenia and their non-psychotic first-degree relatives. Sixty-nine patients with schizophrenia, 56 of their first-degree relatives (33 parents and 23 siblings), and 92 healthy controls (67 younger healthy controls matched to the patients and siblings, and 25 older healthy controls matched to the parents) completed a set of facial emotion perception tasks, including facial emotion discrimination, identification, intensity, valence, and corresponding face identification tasks. The results demonstrated that patients with schizophrenia performed significantly worse than their siblings and younger healthy controls in accuracy in a variety of facial emotion perception tasks, whereas the siblings of the patients performed as well as the corresponding younger healthy controls in all of the facial emotion perception tasks. Patients with schizophrenia also showed significantly reduced speed than younger healthy controls, while siblings of patients did not demonstrate significant differences with both patients and younger healthy controls in speed. Meanwhile, we also found that parents of the schizophrenia patients performed significantly worse than the corresponding older healthy controls in accuracy in terms of facial emotion identification, valence, and the composite index of the facial discrimination, identification, intensity and valence tasks. Moreover, no significant differences were found between the parents of patients and older healthy controls in speed after controlling the years of education and IQ. Taken together, the results suggest that facial emotion perception deficits may serve as potential endophenotypes for schizophrenia. |
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| Keywords: | AIMS Abnormal Involuntary Movements Scale BARS Barnes' Akathisia Rating Scale CPZ chlorpromazine DSM-IV Diagnostic and Statistical Manual of Mental Disorders fourth edition FEDT Facial Emotion Discrimination Test FEIT Facial Emotion Identification Test FEIDT Facial Emotion Intensity Differentiation Test FEVT Facial Emotion Valence Test HC healthy controls IQ intelligence quotient PANSS Positive and Negative Syndrome Scale SANS Scale for the Assessment of Negative Symptoms SPD schizotypal personality disorder SZ schizophrenia TFR Test of Facial Recognition VAPT videotape affect perception test WAIS-R Wechsler Adult Intelligence Scale &mdash Revised |
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