Reduced cardio-respiratory coupling indicates suppression of vagal activity in healthy relatives of patients with schizophrenia |
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| Authors: | Sandy Berger,Michael Karl Boettger,Manuel Tancer,Salvador M. Guinjoan,Vikram K. Yeragani,Karl-Jü rgen Bä r |
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| Affiliation: | 1. Department of Psychiatry and Psychotherapy, University Hospital, Jena, Germany;2. Institute of Physiology, University Hospital, Jena, Germany;3. Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, USA;4. Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina;5. Department of Psychiatry, University of Alberta, Edmonton, Canada;6. Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Ruhr-University, Bochum, Germany |
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| Abstract: | Previous studies have observed reduced vagal modulation in patients with acute schizophrenia and their first-degree relatives, thus suggesting a genetic predisposition. |
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| Keywords: | ANCOVA, analysis of covariance ANOVA, analysis of variance ApEn, approximate entropy CNS, central nervous system ECG, electrocardiogram EDA, electrodermal activity FPI, Freiburger Persö nlichkeitsinventar HF, high frequency HRV, heart rate variability LF, low frequency MANCOVA, multivariate analysis of covariance MANOVA, multivariate analysis of variance PANSS, Positive and Negative Syndrome Scale RMSSD, root mean of squared successive difference RTN, retrotrapezoid nucleus SCID, Structured Clinical Interview for DSM Disorders VRC, ventral respiratory columns |
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