Effects of fasting and gender on ochratoxin A toxicokinetics in F344 rats |
| |
| Authors: | A. Vettorazzi,I.F. Trocó niz,E. Gonzalez-Peñ as,L.A. Corcuera,L. Arbillaga,A.G. Gil,J.M. Nagy,P.G. Mantle,A. Ló pez de Cerain |
| |
| Affiliation: | 1. Department of Nutrition and Food Sciences, Physiology and Toxicology, Faculty of Pharmacy, University of Navarra, Irunlarrea 1, E-31008 Pamplona, Spain;2. Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Navarra, Irunlarrea 1, E-31008 Pamplona, Spain;3. Department of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Navarra, Irunlarrea 1, E-31008 Pamplona, Spain;4. Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, UK;5. Center for Environmental Policy, Imperial College London, London SW7 2AZ, UK |
| |
| Abstract: | Ochratoxin A (OTA) is a mycotoxin that causes renal tumors in rats, particularly in males. In previous kinetic studies performed in fed conditions (Vettorazzi et al., 2008), mature F344 male rats presented a significantly lower OTA bioavailability than females and young animals. The objective of the present study was to evaluate two factors which could explain this different kinetic profile: the presence of food and the male-specific protein alpha-2u-globulin. Therefore, a 24 h kinetic study has been performed in rats under fasting conditions. Food ingestion has been controlled in both sexes during two months. The presence of alpha-2u-globulin in the urine has been analyzed with SDS-gradient mini-gel electrophoresis. |
| |
| Keywords: | Ochratoxin A Toxicokinetic Bioavailability Male and female F344 rat Food Alpha-2u-globulin |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
