伤口愈合水凝胶治疗慢性下肢静脉曲张性溃疡的早期结果

目的 评价伤口愈合水凝胶(商品名奇特生)治疗下肢静脉曲张性溃疡的早期疗效,为治疗下肢静脉曲张性溃疡提供新方法.方法 2007年4-月2007年9月,门诊治疗60例临床分级均为C6级的慢性下肢静脉曲张性溃疡患者,随机分为伤口愈合水凝胶组(A组)和对照组(B组),每组30例.A组男24例,女6例;年龄(57.3±6.8)岁,病程(2.9±0.7)年,溃疡面积(3.4±0.6)cm2.B组男20例,女10例;年龄(60.1±7.4)岁,病程(3.3±0.9)年,溃疡面积(3.1±0.4)cm2.两组差异均无统计学意义(P＞0.05).A组用1mL/cm2伤口愈合水凝胶涂抹于创面,B组用生理盐水纱条覆盖创面治疗.治疗后每周测定两组溃疡面积,治疗15 d评定疗效至溃疡痊愈.结果 A组治疗7 d及14 d溃疡面积分别为(2.6±0.7)及(1.1±0.2)cm2;B组分别为(2.8±0.6)及(2.3±0.7)cm2.两组治疗7d差异无统计学意义(P＞0.05),治疗14 d差异有统计学意义(P＜0.05).A组溃疡愈合时间为(12.0±1.7)d,B组为(31.0±2.9)d,差异有统计学意义(P＜0.01).根据自定评价标准A组治愈16例,显效9例,有效4例,无效1例;B组治愈3例,显效9例,有效14例,无效4例.两组疗效比较,差异有统计学意义(P＜0.01). 结论 伤口愈合水凝胶可有效治疗下肢静脉曲张性溃疡.

A PROSPECTIVE STUDY ON WOUND-HEALING HYDROGEL IN TREATING CHRONIC VENOUS ULCER OF LOWER EXTREMITIES

OBJECTIVE: To study the outcome of wound-healing hydrogel in treating chronic venous ulcer of lower extremities so as to find a new therapy. METHODS: From April 2007 to September 2007, 60 patients with chronic venous ulcer of lower extremities were randomly assigned to wound-healing hydrogel group (group A, 30 cases) and control group (normal saline, group B, 30 cases). In group A, there were 24 males and 6 females, aging (57.3 +/- 6.8) years; the disease course was (2.9 +/- 0.7) years; and the ulcer area was (3.4 +/- 0.6) cm2. In group B, there were 20 males and 10 females, aging (60.1 +/- 7.4) years; the disease course was (3.3 +/- 0.9) years; and the ulcer area was (3.1 +/- 0.4) cm2. There were no differences in age, area of ulcer and course of disease between two groups (P > 0.05). The area of ulcer was measured every week after the treatment, and the effect of treatment was evaluated after 15 days. RESULTS: The ulcer area of 7 days and 14 days after treatment was (2.6 +/- 0.7) and (1.1 +/- 0.2) cm2 in group A, and (2.8 +/- 0.6) and (2.3 +/- 0.7) cm2 in group B, respectively; showing no statistically significant differences 7 days after treatment (P > 0.05), and showing statistically significant difference 14 days after treatment between two groups (P < 0.05). The average healing time was (12.0 +/- 1.7) days in group A, and (31.0 +/- 2.9) days in group B, respectively, showing statistically significant difference (P < 0.01). The results were excellent, good, fair and poor in 16, 9, 4 and 1 of group A, and were in 3, 9, 14 and 4 of group B, respectively; showing statistically significant difference (P < 0.01). CONCLUSION: Wound-healing hydrogel is effective in treating chronic venous ulcer of lower extremities.