二甲双胍对耐克罗米酚的多囊卵巢综合征患者的临床应用

目的 了解二甲双胍对耐克罗米酚的多囊卵巢综合征（PCOS）患者的治疗作用.方法 28例耐克罗米酚PCOS患者经二甲双胍500mg每日三次治疗3个月,观察服药前后内分泌指标、体重指数（BMI）、腰臀围比值（WHR）、月经的变化及再加用克罗米酚促排卵情况.结果 二甲双胍治疗后血黄体生成素/卵泡刺激素比值（LH/FSH）、睾酮（T）、空腹胰岛素均显著降低（P＜0.05）,而BMI、WHR、空腹血糖无明显变化（P＞0.05）,同时二甲双胍治疗后21.43%患者月经恢复正常,再次用克罗米酚促排卵有13例有排卵,排卵率为46.43%,其中4例指导性生活后妊娠.结论 二甲双胍能改善耐克罗米酚PCOS患者的胰岛素抵抗及高雄激素血症,增强耐克罗米酚患者对克罗米酚的敏感性,是目前治疗PCOS新的辅助方法.

Clinical research of metformin in clomiphene-resistant women with polycystic ovary syndrome

Objective] To investigate the treatment of metformin in clomiphene- resistant women with polycystic ovary syndrome (PCOS). Methods] Metformin was given to 28 clomiphene-resistant women with PCOS for 3 months. The levels of hormones, body mass index(BMI), waist to hip ratio(WHR), menstruation and the ovulation rate were measured both before and after the treatment. Results] After three months of the treatment of metformin, the ratio of luteinizing hormone (LH) and follicle stimulating hormone(FSH), testosterone(T), fast insulin were significantly decreased (P <0.05). But there was no significant difference in BMI, WHR and fast glucose(P >0.05). 21.43% patients had normal menstruation. After clomiphene was given repeatly, 46.43% patients had ovulated and 4 cases had pregnancies. Conclusion] Metformin can reduce insulin resistance(IR) and hyperandrogenemia, improve the sensitivity of clomiphene in clomiphene- resistant women with PCOS.It is a new adjuvant treatment in PCOS.