IgA responses during human cytomegalovirus infection in cardiac transplant recipients: concurrent detection of IgA and IgM antiglobulins |
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| Affiliation: | 1. Division of Immunology, Department of Pathology, University of Cambridge, Hills Road, Cambridge, U.K.;2. Clinical Microbiology and Public Health Laboratory, Addenbrooke''s Hospital, Hills Road, Cambridge, U.K.;1. College of Chemical Engineering, State Key Laboratory Breeding of Green Chemistry-Synthesis Technology, Zhejiang University of Technology, Hangzhou 310032, China;2. Department of Environmental Engineering, National Chung Hsing University, 250, Kuo-Kuang Road, Taichung, Taiwan;1. Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97007, USA;2. Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97007, USA;3. Department of Medicine and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21218, USA;4. Biostatistics Shared Resource, Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA;5. Division of Medical Physics, Department of Radiation Medicine, Oregon Health & Science University, Portland, OR 97239, USA;6. Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN, 55454, USA;7. Division of Blood and Marrow Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA;1. State Key Joint Laboratory of Environmental Simulation and Pollution Control, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China;2. University of Chinese Academy of Sciences, Beijing 100049, China;3. Department of Water Pollution Control Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China;4. School of Architecture and Construction, University of South China, Hengyang 421001, China;1. Organic Material Synthesis Laboratory, Department of Chemistry, Incheon National University, Republic of Korea;2. Research Institute of Basic Sciences, Incheon National University, Incheon 22012, Republic of Korea;1. Faculty of Natural Resources and Environment, Thai Nguyen University of Sciences (TNUS), Tan Thinh Ward, Thai Nguyen City, VietNam;2. Faculty of Environment – Natural Resources and Climate Change, Ho Chi Minh City University of Food Industry (HUFI), 140 Le Trong Tan Street, Tay Thanh Ward, Tan Phu District, Ho Chi Minh City, VietNam;3. Faculty of Environment, Thai Nguyen University of Agriculture and Forestry, Thai Nguyen City, VietNam;4. Faculty of Urban Infrastructure Engineering, University of Architecture Ho Chi Minh City, 196 Pasteur Street, Ward 6, District 3, Ho Chi Minh City, VietNam;5. Institute of Research and Development, Duy Tan University, Da Nang 550000, VietNam;6. Laboratory of Advanced Materials Chemistry, Advanced Institute of Materials Science, Ton Duc Thang University, Ho Chi Minh City, VietNam;7. Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, VietNam;1. Yildiz Technical University, Department of Chemistry, 34349 İstanbul, Turkey;2. Siirt University, Faculty of Education, Department of Science Education, 56100 Siirt, Turkey |
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| Abstract: | The serum IgA response to human cytomegalovirus (HCMV) infection was investigated in relationship to IgG serology in cardiac transplant recipients in order to investigate its diagnostic usefulness. Of 19 patients studied 12 were found to have rising titres of IgG antibody to HCMV. Within this group a transitory IgA response with a variable duration (mean of 42 days) was detected in six patients with primary infection and in none of the patients with pre-existing IgG antibody undergoing a reactivation of, or re-infection with, HCMV. No IgA antibody was detected in four patients with constant levels of IgG antibody. An antiglobulin response measured by passive haemagglutination was concurrent with the IgA response. When analysed by solid phase binding assay, serial sera from four of five patients studied were found to have both an IgM anti IgG and an IgA anti IgG component to the antiglobulin response. The specificity of the HCMV-IgA response was, however, confirmed, because treatment of sera to remove antiglobulin failed to abrogate virus specific antibody. |
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