| 鞣花鞣质肠道代谢产物urolithins研究进展 |
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| 引用本文： | 周本宏,邱振鹏,易慧兰,周丁山,汪静,吴玥.鞣花鞣质肠道代谢产物urolithins研究进展[J].中国中药杂志,2016,41(16):2968-2974. |
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| 作者姓名： | 周本宏 邱振鹏 易慧兰 周丁山 汪静 吴玥 |
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| 作者单位： | 武汉大学 人民医院, 湖北 武汉 430060,湖北中医药大学 中药资源与中药复方教育部重点实验室, 湖北 武汉 430065,武汉大学 人民医院, 湖北 武汉 430060,武汉大学 人民医院, 湖北 武汉 430060,武汉大学 人民医院, 湖北 武汉 430060,武汉大学 人民医院, 湖北 武汉 430060 |
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| 基金项目： | 国家公益性行业专项（201407002）；江苏高校优势学科建设工程项目（PAPD）；江苏省青蓝工程 |
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| 摘 要： | 鞣花鞣质是一类具有诸多生物活性的酚类化合物,近年来研究发现其发挥作用的物质基础与其肠道菌群代谢产物——尿石素密切相关。该研究就近几年国内外关于尿石素的结构特征、类型、分布,以及其改善前列腺、乳腺、结肠相关疾病,抗癌、抗氧化、抗炎等生物活性研究进行了综述,为开发和利用尿石素奠定基础。
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| 关 键 词： | 尿石素 代谢产物 分布 生物活性 |
| 收稿时间： | 2016/3/14 0:00:00 |
Research progress of ellagitannin intestinal metabolite urolithins |
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| ZHOU Ben-hong,QIU Zhen-peng,YI Hui-lan,ZHOU Ding-shan,WANG Jing and WU Yue.Research progress of ellagitannin intestinal metabolite urolithins[J].China Journal of Chinese Materia Medica,2016,41(16):2968-2974. |
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| Authors: | ZHOU Ben-hong QIU Zhen-peng YI Hui-lan ZHOU Ding-shan WANG Jing and WU Yue |
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| Institution: | Renmin Hospital of Wuhan University, Wuhan 430060, China,Key Laboratory of Traditional Chinese Medicine Resources and Traditional Chinese Medicine Compounds, Ministry of Education, Hubei University of Chinese Medicine, Wuhan 430065, China,Renmin Hospital of Wuhan University, Wuhan 430060, China,Renmin Hospital of Wuhan University, Wuhan 430060, China,Renmin Hospital of Wuhan University, Wuhan 430060, China and Renmin Hospital of Wuhan University, Wuhan 430060, China |
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| Abstract: | Ellagitannins is a kind of phenolic compounds with many biological activities. Recent studies have found that the effective ingredients of these compounds have close relationship with their colon-derived bacteria metabolites, that is urolithins. The objective of this study was to review the structure characteristics, types and distribution of urolithins, improvement in diseases related to prostate, breast and colon, as well as anti-cancer, anti-oxidation, anti-inflammation and other biological activities. The present review will lay the foundation for development and utilization of urolithins. |
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| Keywords: | urolithins metabolite distribution biological activity |
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