| 刘寄奴化学成分研究 |
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| 引用本文： | 肖同书,王 琼,蒋骊龙,蒋建勤,李友宾.刘寄奴化学成分研究[J].医学教育探索,2013,44(4):515-518. |
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| 作者姓名： | 肖同书 王 琼 蒋骊龙 蒋建勤 李友宾 |
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| 作者单位： | 1.中国药科大学 天然药化教研室，江苏 南京 211199 2.江苏省中医药研究院 中药化学教研室，江苏 南京 210028 3.南京中医药大学，江苏 南京 210028 |
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| 基金项目： | 江苏省六大人才高峰项目（2012-YY-011） |
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| 摘 要： | 目的 研究刘寄奴Artemisia anomala的化学成分。方法 采用溶剂法和多种柱色谱法进行分离纯化，并经波谱分析鉴定化合物的结构。结果 从刘寄奴95%乙醇提取物的醋酸乙酯部位分离得到7个化合物，分别鉴定为 (4aS, 7S, 7aR)-7-羟基-7-甲基-1, 4a, 5, 6, 7, 7a-六氢环戊二烯 c] 吡喃-4-羧酸甲酯（1）、rehmaglutin D（2）、(E)-6-羟基-2, 6-二甲基辛-2, 7-二烯酸（3）、金圣草酚（4）、木犀草素（5）、芹菜素（6）、对羟基苯丙烯酸（7）。结论 其中化合物1为新的环烯醚萜，命名为刘寄奴醚萜；化合物2为首次从该属植物中分离得到，化合物3、4和7为首次从该植物中分离得到。
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| 关 键 词： | 刘寄奴 环烯醚萜 刘寄奴醚萜 rehmaglutin D 圣黄草素 对羟基苯丙烯酸 |
Chemical constituents of Artemisia anomala |
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| XIAO Tong-shu,WANG Qiong,JIANG Li-long,JIANG Jian-qin,LI You-bin.Chemical constituents of Artemisia anomala[J].Researches in Medical Education,2013,44(4):515-518. |
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| Authors: | XIAO Tong-shu WANG Qiong JIANG Li-long JIANG Jian-qin LI You-bin |
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| Institution: | 1.Department of Phytochemistry, China Pharmaceutical University, Nanjing 211199, China 2.Department of Natural Medicinal Chemistry, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, China 3.Nanjing University of Chinese Medicine, Nanjing 210028, China |
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| Abstract: | Objective To study the chemical constituents of Artemisia anomala. Methods Various chromatographic techniques were adopted to separate the constituents, and the spectroscopic analysis was used to identify their structures. Results Seven compounds were isolated and identified as (4aS, 7S, 7aR)-methyl 7-hydroxy-7-methyl-1, 4a, 5, 6, 7, 7a-hexahydrocyclopenta c] pyran-4- carboxylate (1), rehmaglutin D (2), (E)-6-hydroxy-2, 6-dimethylocta-2, 7-dienoic acid (3), chrysoeriol (4), luteolin (5), apigenin (6), and p-coumaric acid (7). Conclusion Compound 1 is a new compound named artanoiridoid; Compound 2 is firstly reported in this genus; Compounds 3, 4, and 7 are separated from this plant for the first time. |
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| Keywords: | Artemisia anomala S Moore iridoid artanoiridoid rehmaglutin D chrysoeriol p-coumaric acid |
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