| 青椒碱对实验性肝癌细胞骨架影响的电镜观察 |
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| 引用本文： | 白锦雯,张颖,杨美娟,吴菁. 青椒碱对实验性肝癌细胞骨架影响的电镜观察[J]. 北京中医药大学学报, 2000, 23(4): 27-29 |
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| 作者姓名： | 白锦雯 张颖 杨美娟 吴菁 |
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| 作者单位： | 北京中医药大学组织胚胎学教研室,北京100029 |
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| 基金项目： | 国家自然科学基金资助课题!(No.39370843) |
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| 摘 要： | 用二乙基亚硝胺 (DEN)诱发大鼠肝癌动物模型 ,以青椒碱治疗 ,分离肝细胞原代培养 ,应用整装细胞电镜技术结合选择性抽提观察细胞骨架。结果显示DEN诱发大鼠肝癌细胞的骨架丝状结构遭到破坏、断裂并聚集成团块 ,治疗组细胞骨架有明显的恢复。提示青椒碱可通过影响细胞骨架对大鼠实验性肝癌细胞起到治疗作用
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| 关 键 词： | 细胞骨架 电镜技术 肝癌 细胞培养 青椒碱 |
Effects of Schinifoline on Cytoskeleton of Experimental Hepatoma in Rats Observed by Whole Mount Cell Transmission Electron Microscopy |
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| Bai Jinwen. Effects of Schinifoline on Cytoskeleton of Experimental Hepatoma in Rats Observed by Whole Mount Cell Transmission Electron Microscopy[J]. Journal of Beijing University of Traditional Chinese Medicine, 2000, 23(4): 27-29 |
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| Authors: | Bai Jinwen |
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| Abstract: | Whole mount cell transmission electron microscopy combined with selective extraction method was adopted to study the effect of schinifoline on hepatocellular cytoskeleton of experimental hepatoma. It was shown that the filaments of the cytoskeletons of the transformed cells induced by DEN were obviously damaged, depolymerized and aggregated. After the treatment with schinifoline, the cytoskeletal system of the transformed cells recovered apparently. So schinifoline can be used to treat on the experimental liver cancer cells in rat by influencing cytoskeleton. |
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| Keywords: | Cytoskeleton Electron microscopy Hepotoma Cell culture Schinifoline |
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