弥可保、凯时和金纳多联合治疗老年糖尿病周围神经病变的临床观察

目的了解弥可保、凯时和金纳多联合治疗在改善糖尿病患者周围神经疼痛及感觉异常方面的作用,为临床治疗糖尿病周围神经病变提供参考。方法以老年Ⅱ型糖尿病患者伴周围神经病变为研究对象,给予弥可保、凯时和金纳多联合治疗,动态观察患者的局部神经疼痛、感觉异常和神经传导速度的改善情况。结果共纳入54例临床诊断为Ⅱ型糖尿病伴周围神经病变的患者。在给予联合治疗4周后,54例患者中分别有24例（44.4%）和25例（46.3%）患者的局部自发痛或（和）感觉异常缓解程度达到了临床显效和有效的标准,而仅5例（9.3%）患者的局部不适无改善。结论弥可保、凯时和金纳多联合治疗对改善老年糖尿病周围神经病变疗效显著。

The clinical observation of the efficacy of mecobalami,alprostadil,and extract of ginkgo biloba leaves combination therapy in elderly diabetic peripheral neuropathy

Objective To investigate the efficacy of mecobalami,alprostadil,and extract of ginkgo biloba leaves combination therapy in reducing pain and paresthesia of diabetic patients and provide a reference for the clinical treatment of diabetic peripheral neuropathy.Methods The elderly type 2 diabetic patients with peripheral neuropathy were given mecobalami,alprostadil,and extract of ginkgo biloba leaves treatment,and the improvement of local nerve pain,paresthesia and nerve conduction velocity were dynamically observed.Results A total of 54 elderly type 2 diabetic patients with peripheral neuropathy were included in this study.After giving 4 weeks of combination therapy,there were 24(44.4%) and 25(46.3%) patients respectively,whose local spontaneous pain or paresthesia remission degree reached to markedly effective standard and effective standard;and only 5 patients had no improvement on local discomfort.Conclusion The combination therapy of mecobalami,alprostadil,and extract of ginkgo biloba leaves could significantly improve the remission of diabetic peripheral neuropathy.