U-74389G PRETREATMENT ATTENUATING WARM ISCHEMIA INJURY IN LIVER TRANSPLANTATION |
| |
作者姓名: | 严佶祺 李宏为 张明钧 杨卫平 蔡伟耀 林言箴 |
| |
作者单位: | DepartmentofSurgery,RuijinHjospital,SSMU,Shanghai200025,China |
| |
摘 要: | Objective To investigate the protective role of lazaroid U-74389G pretreatment against warm ischemia injury of rat liver transplantation from non-heart-beating donors. Methods Rat othortopic liver transplantation was perfomed in 4 groups (N-45, N-60, pN-45 and pN-60 ), according to pretreatment with U-74389G or not, and the non-heart-beating time 45rain or 60rain before donor liver harvested. Survival rates, liver functions, MDA values and graft pathology of each group were compared. Results The one-week survival rates of Group N-45, N-60 , pN-45 and pN-60 were25% (2/8), 0% (0/8), 58.3% (7/12) and 33.3% ( 4/12 ), respectively. U-74389G pretreatment significantly increased survival rate of rat liver trans-plantation from non-heart-beating donors, but also improved liver functions and graft pathologies, as well as decreased MDA expression. Conclusion U-74389G pretreatment could attenuate warm ischemia reperfusion injury of rat liver transplantation from non-heart-beating donors.
|
关 键 词: | 缺血再灌注损伤 U-74389G 缺血预处理 肝脏移植 |
U-74389G PRETREATMENT ATTENUATING WARM ISCHEMIA INJURY IN LIVER TRANSPLANTATION |
| |
Abstract: | Objective To investigate the protective role of lazaroid U-74389G pretreatment against warm ischemia injury of rat liver transplantation from non-heart-beating donors. Methods Rat othortopic liver transplantation was perfomed in 4 groups (N-45, N-60 , pN-45 and pN-60 ), according to pretreatrnent with U-74389G or not, and the non-heart-beating time 45min or 60min before donor liver harvested. Survival rates, liver functions, MDA values and graft pathology of each group were compared. Results The oneweek survival rates ofGroupN-45, N-60 , pN-45 and pN-60 were25% (2/8), 0% (0/8), 58.3% (7/12)and 33.3% ( 4/12 ), respectively. U-74389G pretreatment significantly increased survival rate of rat liver transplantation from non-heart-beating donors, but also improved liver functions atd graft pathologies, as well as decreased MDA expression. Conclusion U-74389G pretreatment could attenuate warm ischemia reperfusion injury of rat liver transplantation from non-heart-beating donors. |
| |
Keywords: | liver transplantation warm ischemia injury U-74389G pretrearment |
本文献已被 维普 万方数据 等数据库收录! |
|