高敏C反应蛋白与高血压病心房颤动的相关性研究

目的探讨血清高敏C反应蛋白（hs—CRP）在高血压心房颤动发生和发展中的作用。方法采用胶乳免疫增强比浊法测定157例原发性高血压患者血清hs—CRP，其中阵发性房颤34例、持续性房颤37例、永久性房颤38例；单纯高血压48例作为对照组。结果心房颤动组和对照组的hs-CRP分别为（9．75±1．08）mg／L、（3．34±0．53）mg／L，左房内径分别为（43．5±8．5）mm、（31．6±4.3）mm，心房颤动组的hs—CRP和左房内径高于对照组（P〈0．01）；持续性房颤组、永久性房颤组和阵发性房颤组的hs—CRP分别为（10．23±1．16）mg/L、（11．34±1．35）mg／L和（7．87±0．59）mg／L，左房内径分别为（45．7±8．9）mm、（47．1±9．7）mm和（37．2±5．8）mm，持续性房颤组和永久性房颤组的hs—CRP和左房内径均明显高于阵发性房颤组（P〈0．05）；而持续性房颤组hs-CRP、左房内径与永久性房颤组差异无统计学意义（P〉0．05）。左房内径与hs—CRP水平呈正相关（r=0．58，P〈0．05）。结论心房颤动患者hs—CRP明显升高，提示炎症反应在高血压心房颤动的发生、发展中起一定作用。

The correlation study of serum hypersensitive C-reactive protein (hs-CRP) and atrial fibrillation in hypertension patients

Objective To study the correlation between atrial fibrillation of hypertension and serum hypersensitive C-reactive protein （hs-CRP）. Methods The immunochemistry method was used to determine the levels of serum hs-CRP in 157 patients with hypertension,including paroxysmal atrial fibrillation （n=34）,long- enduring atrial fibrillation （n =37）, persistence atrial fibrillation （n =38）, paroxysmal atrial fibrillation （n =48 ）. Results The hs-CRP levels in atrial fibrillation group and hypertension control group were （9.75±1.08）mg/L, and （3.34±0.53）mg/L,left atrial internal diameter were （43.5±8.5）mm and （31.6±4.3）mm. The serum concentrations of hs-CRP and left atrial internal diameter in atrial fibrillation group were significatly higher than those in hypertension control group （P〈0.01）. The hs-CRP levels in long-enduring atrial fibrillation,persistence atrial fibrillation group and paroxysmal atrial fibrillation group were （ 10.23 ± 1.16 ）mg/L, （ 11.34 ± 1.35 ）mg/L vs （7.87±0.59）mg/L, left atrial internal diameter were （45.7±8.9）mm, （47.1 ±9.7 ）mm vs （ 37.2±5.8 ）mm. The serum concentrations of hs-CRP and left atrial internal diameter of long-enduring atrial fibrillation and persistence atrial fibrillation group were significatly higher than those in paroxysmal atrial fibrillation group （P〈0.05）,but the serum concentrations of hs-CRP and left atrial internal diameter were no difference between long-enduring atrial fibrillation and persistence atrial fibrillation group （P〉0.05）. The serum concentrations of hs-CRP was positively related with left atrial internal diameter （r=0.58,P〈0.05）. Conclusion The serum hs-CRP significantly increase in patients with atrial fibriliation,it indicates that the inflammatory reaction may possess certain effect in the occurrence and development of atrial fibrillation of hypertension.