心力衰竭患者血浆脑钠素含量及其与左心功能关系研究

目的探讨心力衰竭患者血浆脑纳素(BNP)水平与心力衰竭严重程度、左室功能等因素的关系。方法采用免疫放射分析法测定122例心力衰竭患者治疗前后和20例对照组血浆BNP浓度;用心脏彩色多普勒超声诊断仪测定并比较各组左室射血分数(LVEF)、左心室舒张末期内径(LVEDD)。结果心力衰竭患者BNP浓度显著高于对照组(P<0.01);BNP水平随着心功能NYHA分级程度的加重而显著增高,其与LVEF呈负相关(r=-0.34,P<0.001),而与LVEDD呈正相关(r=0.65,P<0.001),治疗后随心功能好转BNP浓度下降,LVEF和LVEDD明显改善(P<0.05)。结论心力衰竭患者血BNP水平随着心力衰竭严重程度的增加而升高,并能较好反映左室功能状态。

A study of the correlation between the serum brain natriuretic peptide levels and the left cardiac function in patients with heart failure

Objective To investigate the correlation between the serum brain natriuretic peptide(BNP) levels and the severity of heart failure (HF) as well as left ventricular function (LVF) in patients with heart failure.Methods 122 patients with HF before and after treatment and 20 control subjects were investigated by measuring the serum BNP levels, the left ventricular ejection fraction (LVEF) and left ventricular end-diastolic diameter (LVEDD).Results The serum BNP levels in patients with HF were markedly higher than those of control subjects (P<0.01), and the increase of BNP levels was closely correlated with the severity of NYHA functional class. The BNP levels were correlated negatively with the LVEF (γ=-0.34,P<0.001) and positively with the LVEDD (γ=0.65,P< 0.001 ).After treatment LVEF and LVEDD in patients with HF were obviously improved (P<0.05), however,the serum BNP levels were significantly decreased with the improvement of cardiac function.Conclusion The increase of BNP levels is closely correlated with the severity of HF, further more,the BNP levels may reflect the LVF clearly.