阿托伐他汀钙在胺碘酮转复持续性心房颤动中的作用观察

目的探讨阿托伐他汀钙联合胺碘酮转复持续性心房颤动(简称房颤)及房颤复律后维持窦性心律的作用及其对血清炎症反应的影响。方法 68例持续性房颤患者,随机分为两组。对照组34例给予胺碘酮,治疗组34例给予胺碘酮和阿托伐他汀钙。两组均连续服药6个月,观察房颤转复后窦性心律维持率及转复前后血清高敏C反应蛋白(hs-CRP)、白介素6(IL-6)、肿瘤坏死因子α(TNF-α)变化。结果治疗组房颤转复率、窦性心律维持率均较对照组高(79.41%vs 61.76%,76.47%vs 55.88%,P均<0.05),对照组治疗前后hs-CRP、IL-6、TNF-α无变化(P>0.05),治疗组治疗后hs-CRP、IL-6、TNF-α明显降低(P<0.05)。结论阿托伐他汀钙可以降低房颤的复发,其机制可能与抗炎作用相关。

Treatment with atorvastatin and amiodarone in patients with persistent atrial fibrillation.

Objective To investigate the preventive effective of atorvastatin and amiodarone on recurrence of persistent atrial fibrillation, maintenance rate of sinus rhythm and change of inflammatory factors. Methods Sixty-eight patients with persistent atrial fibrillation were randomly divided into control group （ n = 34, treated with amiodarone） and treated group （n = 34, treated with amiodarone and atorvastatin）. After 6 months follow-up, observe the change of hs-CRP , IL-6, TNF-α and maintenance rate of sinus rhythm before and after treatment. Results After treatment, sinus rhythm of control group and treated group was 61.76% vs 79.41% （P 〈 0.05 ）, maintenance rate of sinus rhythm in control group and treated group was 55.88% vs 76.47% （P 〈 0.05）. The hs-CRP , IL-6 and TNF-α in control group had no difference before and after treatment （ P 〉 0.05 ）, while in treated group which greatly decreased after treatment （ P 〈 0.05 ）. Conclusion Atorvastatin may reduce recurrence of persistent atrial fibrillation, which is related to is anti-inflammation effect.