氟比洛芬酯和利多卡因联用缓解异丙酚注射痛的随机对照研究

目的 探讨联合应用氟比洛芬酯和利多卡因做静脉预处理缓解异丙酚注射痛的效果.方法 将160例拟行择期手术的ASI 1～2级全麻患者随机分为对照组、利多卡因组(Lc组)、氟比洛芬酯组(FA组)和氟比洛芬酯和利多卡因联用组(联用组),每组各40例.所有患者在给药前均先以橡胶止血带阻断其局部静脉回流,随后分别给予对照组0.9％ NS7 mL,FA组氟比洛芬酯注射液5mL(50 mg)+0.9％ NS 2 mL,Lc组2％利多卡因2mL(40 mg)+0.9％ NS 5 mL,联用组氟比洛芬酯注射液5mL (50 mg) +2％利多卡因2mL (40 mg);2 min后撤止血带,在5s内给入0.5 mg/kg的异丙酚.给药同时由另一位麻醉师以相同的方式及问题询问患者注射部位情况,采用VRS评分.结果 4组间一般情况比较无明显差异.Lc组、FA组、联用组的异丙酚注射痛发生率明显低于对照组(P＜0.05),联用组疼痛发生率低于其余3组.在注射痛强度评分方面,Lc组和联用组的疼痛强度明显低于对照组.术后24 h随访,患者注射部位无红肿、静脉炎或药疹等不良反应情况,亦无预期的胃肠刺激症状.结论 氟比洛芬酯和利多卡因联用做静脉预处理可有效缓解异丙酚注射痛,且不会增加不良反应.

Pretreatment with Mixture of Flurbiprofen Axetil and Lidocaine in Reducing Injection Pain of Propofol: A Randomized Controlled Trial

Objective To investigate the effectiveness of pretreatment with mixture of lidocaine and flurbiprofen axetil in reducing injection pain of propofol.Methods One hundred and sixty ASI I–II patients undergoing general anaesthesia were randomly allocated into four groups（40 cases in each group）： the control group,the lidocaine（Lc） group,the flurbiprofen axetil（FA） group and the mixture of lidocaine and flurbiprofen axetil（hereafter termed as ＂mixture＂） group.After the occlusion of venous drainage,patients were pretreated with 7 mL of 0.9% saline in the control group,5？mL（50 mg） of flurbiprofen axetil and 2 mL of 0.9% saline in the FA group,2 mL（40 mg） of 2% lidocaine and 5 mL of 0.9% saline in the Lc group,and 5 mL（50 mg） of flurbiprofen axetil and 2 mL（40 mg） of 2% lidocaine in the mixture group,respectively.The occlusion was released 2 min later and then 0.5 mg/kg propofol was injected into the vein within 5 s.During injecting propofol,the patients were asked by another anesthetist to assess and record their pain through using VSR.Results No significant differences in the demographic characteristics were found among the four groups.In comparison with the control group,the incidence rates of propofol injection pain were obviously lower in the mixture group,the FA group and the Lc group（P0.05）;there was a significant reduction in the incidence rate of pain in the mixture group compared with the other three groups.The median pain score was significantly lower in the mixture group and the Lc group than that in the control group.During the 24 hour follow-up after operation,neither the adverse events such as red-swelling in injection site,phlebitis or drug eruption,nor the gastrointestinal stimulating signs were found.Conclusion The mixture of flurbiprofen axetil and lidocaine is found to be more effective in reducing injection pain of propofol.