| 热休克蛋白60与心房颤动的关系 |
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| 引用本文： | 陈卓宏,伍伟锋,曾知恒,黄凯.热休克蛋白60与心房颤动的关系[J].中国心脏起搏与心电生理杂志,2011,25(5):409-410. |
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| 作者姓名： | 陈卓宏 伍伟锋 曾知恒 黄凯 |
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| 作者单位： | 广西医科大学第一附属医院心内科,广西 南宁,530021 |
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| 基金项目： | 广西教育厅自然基金资助项目 |
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| 摘 要： | 目的探索心房颤动(简称房颤)与氧化应激的关系。方法以住院行心脏换瓣手术的病人作为研究对象,按患者心律分为房颤组(n=22)和对照组(n=20),对照组为窦性心律。所有研究对象的心房肌组织样本,均作病理形态学观察,并用免疫组织化学法检测其热休克蛋白60(HSP60)表达;用乳胶增强免疫比浊法测定其血清C-反应蛋白(CRP)水平。结果房颤病人的心肌细胞肥大与间质纤维化程度都比对照组明显。HSP60表达阳性率房颤组高于对照组(68.2%vs 25.0%),灰度值房颤组低于对照组(157.69±16.00 vs 178.69±28.63)。血清CRP含量房颤组高于对照组(20.72±17.92 mg/L vs 6.80±6.26 mg/L,P均<0.05)。结论氧化应激与房颤关系密切。
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| 关 键 词： | 心血管病学 心房颤动 氧化应激 C-反应蛋白 热休克蛋白60 |
The relationship between heat shock protein-60 and atrial fibrillation. |
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| CHEN Zhuo-hong,WU Wei-feng,ZENG Zhi-heng,HUANG Kai.The relationship between heat shock protein-60 and atrial fibrillation.[J].Chinese Journal of Cardiac Pacing and Electrophysiology,2011,25(5):409-410. |
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| Authors: | CHEN Zhuo-hong WU Wei-feng ZENG Zhi-heng HUANG Kai |
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| Institution: | CHEN Zhuo-hong,WU Wei-feng,ZENG Zhi-heng,HUANG Kai.Department of Cardiology,the First Affiliated Hospitial of Guangxi Medicial University,Guangxi 530021,China |
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| Abstract: | Objective To investigate the relationship between atrial fibrillation(AF) and oxidative stress.Methods Forty-two of in-patients who were operated for valve replacement served as the subjects of this study;The AF group was composed of 22 AF patients and the control group was composed of 20 patients with sinus rhythm.Atrial muscle samples of all subjects were examined pathologically for morphology characteristics.Serum heat-shock-protein 60(HSP60) expression levels were detected by means of immuno-histo-chemi... |
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| Keywords: | Cardiology Atrial fibrillation Oxidative stress C-reactive protein Heat shock protein-60 |
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