8种抗生素透入犬胰组织能力的实验研究

为了解抗生素渗透胰组织的能力，以便为选择合适的抗生素治疗继发性胰腺感染提供参考依据。作者在建立犬急性出血坏死性胰腺炎模型的基础上，应用高效液相色谱法测定犬血清和胰组织中抗生素的浓度，并计算出它们的胰组织渗透率。结果：头孢噻肟，氧氟沙星，丁胺卡那霉素，氧哌嗪肯青霉素，头孢哌酮，氨苄青霉素，甲硝唑和环丙沙星的胰组织渗透率由小到大依次为１２％，１９％，２０％，４６％，５５％，６３％，７１％和１３２％。

AN EXPERIMENTAL STUDY ON PERMEABILITY OF ANTIBIOTICS TO PANCREATIC TISSUE

In order to choose the appropriate antibiotics for treating secondary pancreatic infection, permeability of antibiotics to pancreatic tissue was investigated on experimental dogs with acute hemorrhagic necrotizing pancreatitis. The concentrations of 8 different antibiotics were determined in the blood and the pancreatic tissue using high performance liquid chromatography. Pancreatic tissue permeability of Cefotaxime, Ofloxacin, Amikacin, Piperacllin, Cefoperazone, Ampicillin, Metronidazole and Ciprofloxacin was 12%, 19%, 20%, 46%, 55%, 63%, 71% and 132% respectively. The study shows that this eight antibiotics have different permeability to the pancreatic tissue. Such observations support the existence of a blood pancreas barrier, which acts to restrict the permeation of antibiotics into the pancreas. The results suggest that antibiotics with high permeability rate be used to treat the patient with secondary pancreatic infection.