血清Cys-c和Hcy对冠状动脉病变严重程度的评估及瑞舒伐他汀的干预作用

目的：观察瑞舒伐他汀干预后不同严重程度的冠心病患者血清Cys-c和Hcy水平的变化。方法选择来我院就诊经冠状动脉造影确诊为冠心病患者40例（冠脉单支病变11例、冠脉双支病变16例和冠脉多支病变13例），分为两组（n＝40）：瑞舒伐他汀治疗前组和瑞舒伐他汀治疗后组（瑞舒伐他汀10mg/d），同期体检健康人20例作为正常对照组；初次检查、治疗6个月后均空腹采血及冠状动脉造影。采用ELISA法检测血清中Cys-c和Hcy的水平；采用冠状动脉造影测定斑块的个数、厚度、性质。结果（1）治疗前与正常对照组相比较，患者血清Cys-c和Hcy水平均显著升高有统计学意义（P＜0．01）；均为冠脉多支病变高于冠脉双支病变及冠脉单支病变，组间比较有统计学意义（P＜0．01）。（2）治疗后与正常对照组相比较，瑞舒伐他汀干预组患者血清Cys-c和Hcy水平略升高且冠脉多支病变、冠脉双支病变、冠脉单支病变组均明显低于治疗前（P＜0．01），但三组间无统计学意义（P＞0．05）。（3）瑞舒伐他汀干预组治疗后患者血清Cys-c和Hcy水平明显低于治疗前有统计学意义（P＜0．01），斑块个数无差异（P＞0．05），斑块厚度变薄、斑块由软斑块变为硬斑块的百分率大（P＜0．01）。结论血清Cys-c和Hcy水平随病变严重程度而升高，瑞舒伐他汀能通过降低血清Cys-c和Hcy水平，使得斑块变薄，并能促进斑块硬化，从而改善冠心病患者冠状动脉病变的程度。

Cys-c and Hcy in serum for the severity of coronary artery disease assessment and the intervention effect of rosuvastatin

Objective To observe the change of Cys-c and Hcy level in the serum of the coronary heart disease pa-tients with different severity after the intervention of rosuvastatin.Methods Options to our hospital diagnosed by coro-nary angiography 40 patients with coronary heart disease （single vessel coronary artery disease 1 1 cases,dual vessel cor-onary artery disease 16 cases,multi-vessel coronary artery disease 13 cases）,divided into two groups（n=40）：Before treatment with rosuvastatin group and rosuvastatin treatment group（rosuvastatin 10 mg/d）,physical health of people 20 cases over the same period as the normal control group;Initial inspection,after 6 months of treatment both fasting blood and coronary angiography.Detected by ELISA in serum Cys-c and Hcy level;Measured by coronary angiography＆amp;nbsp;plaque number,thickness,nature.Results （1）Before treatment compared with the control group,Cys-c and Hcy level in the serum of the patients were significantly higher statistically significant（P〈0.01）;Coronary multi-vessel disease are higher than double coronary artery disease and higher than single vessel disease and have statistically significant（P〈0.01）;（2）After treatment compared with the control group,Cys-c and Hcy level in the serum of rosuvastatin inter-vention groups were slightly elevated and among multi-vessel disease,double coronary artery disease and single vessel coronary artery disease was not statistically significant（P＆gt;0.05）.（3）Rosuvastatin intervention groups the levels of Cys-c and Hcy in the serum were significantly lower than before treatment was statistically significant（P〈0.01）,no difference in the number of plaques（P＆gt;0.05）,plaque thickness thining spots large blocks into soft plaque and hard plaque percentage（P〈0.01）.Conclusion Serum Cys-c and Hcy levels increased with disease severity,rosuvastatin by reducing serum Cys-c and Hcy levels,making the plaque thining and promote plaque sclerosis,thereby improving coro-nary heart dise