兔早期肝硬化形成中CT灌注成像的实验研究

目的 探讨兔早期肝硬化形成过程中血流动力学的变化规律。方法 实验设四氯化碳诱导和正常对照2组各15只新西兰大白兔，分别每2周对实验组3只，正常对照组3只进行多层螺旋CT肝脏灌注成像扫描，用肝脏灌注分析软件取得不同病变阶段肝实质的灌注参数，同时作相应的病理学观察，进行对照研究和统计学分析。结果 自2周末至10周末，实验组肝动脉灌注量（HAP）呈升高趋势。对照组兔和实验组兔第2周末与实验组兔第4周末HAP变化无统计学意义。但与第6周末、第8及10周末HAP变化均有统计学意义（P〈0.05）。门静脉灌注量（HPP）和肝血流量（HBF）均呈下降趋势。平均通过时间（MTT）逐渐延长。三者与肝动脉灌注量的变化具有类似的统计学结果。结论 肝脏CT灌注参数可定量测定肝脏血流变化，可反映早期肝硬化形成过程中的血流动力学改变。因此，肝脏血流灌注参数改变对肝脏疾病的早期诊断、治疗和疗效观察有重要价值。

Experimental study of CT perfusion in early stage of cirrhosis of rabbits

Objective To investigate the changes of hepatic blood perfusion in rabbits in early stage of cirrhosis. Methods Fifteen New Zealand rabbits of control group and 15 of test group were enrolled in this study. The rabbits in the test group were induced with CCl4, and 3 were studied with CT perfusion with 2 weeks intervals. Meanwhile, the CT perfusion data of different stages were compared and pathologic analysis was performed. Results Between the period of fourth week and tenth week of test, hepatic artery perfusion (HAP) trended to increase in test group. Statistic analysis showed the differences of hepatic artery flow (HAF) at different stages were significant between control and test groups (P<0.05). Hepatic blood flow (HBF) and hepatic portal perfusion (HPP) declined, mean transmit time (MTT) prolonged obviously, and all showed similar statistic results. Conclusion CT perfusion can reflect some changes of hepatic blood perfusion in rabbits in early stage of cirrhosis. The data of CT perfusion, especially the changes should be valuable for clinical early diagnosis, treatment and follow-up.