| 三氧化二砷抑制肝癌细胞增殖的体内实验研究 |
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| 引用本文： | 唐印华 刘铁夫 等. 三氧化二砷抑制肝癌细胞增殖的体内实验研究[J]. 哈尔滨医药, 2003, 23(1): 3-4 |
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| 作者姓名： | 唐印华 刘铁夫 等 |
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| 作者单位： | 哈尔滨医科大学附属第一医院 150001(唐印华，刘铁夫，庄丽维，姜爱民)，哈尔滨医科大学附属第一医院 150001(梁桃) |
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| 摘 要： | 目的：探讨As2O3对小鼠H22肝癌细胞增殖的抑制作用。方法：建立小鼠H22肝癌实体型移植瘤模型，腹腔应用As2O3治疗后，通过PCNA及CyclinD1免疫组化检测指标反映细胞增殖改变。结果：As2O3能够下调PCNA及CyclinD1蛋白的表达。结论：As2O3对小鼠肝癌细胞的增殖具有明显的抑制作用，具有治疗肝癌潜在价值。
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| 关 键 词： | 实验研究 三氧化二砷 肝癌 移植 免疫组织化学 |
In vivo study on proliferation inhibition by arsenic trioxide in liver cancer |
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| Tang yinhua Liu tiefu,et al.. In vivo study on proliferation inhibition by arsenic trioxide in liver cancer[J]. harbin medical journal, 2003, 23(1): 3-4 |
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| Authors: | Tang yinhua Liu tiefu et al. |
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| Affiliation: | Tang yinhua Liu tiefu,et al. Department of digestive First affiliated hospital Harbin Medical University. Harbin,150001) |
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| Abstract: | Objective To explore the inhibition of proliferation by arsenic trioxide(As2O3) in mice liver cancer. Methods Mice bearing H22 solid liver cancer cells were treated with defferent density arsenic triox-ide. PCNA and CyclinD1 of tumor cells were studied by immunohistochemical methods. Results PCNA and CyclinD1 positive cells of As2O3 - treated groups were obviously lower than those of controls. Conclusion Animal experiment proved that As2O3 can obviously inhibit the proliferation of mice H22 liver cancer cells. |
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| Keywords: | arsenic trioxide hepatoma transplant immunohistochemistry |
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