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The management of pregnancy in Gaucher disease |
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| Authors: | Granovsky-Grisaru Sorina Belmatoug Nadia vom Dahl Stephan Mengel Eugen Morris Elizabeth Zimran Ari |
| Institution: | a Imperial College London, Hammersmith Campus, London, UK b Imaging Science Department, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital Campus, London, UK c Centre for Fetal Care, Queen Charlotte's and Chelsea Hospital, Imperial College Healthcare Trust, UK |
| Abstract: | Magnetic Resonance Imaging (MRI) has become an established technique in fetal medicine, providing complementary information to ultrasound in studies of the brain. MRI can provide detailed structural information irrespective of the position of the fetal head or maternal habitus. Proton Magnetic Resonance Spectroscopy (1HMRS) is based on the same physical principles as MRI but data are collected as a spectrum, allowing the biochemical and metabolic status of in vivo tissue to be studied in a non-invasive manner. 1HMRS has been used to assess metabolic function in the neonatal brain but fetal studies have been limited, primarily due to fetal motion. This review will assess the technique and findings from fetal studies to date. |
| Keywords: | Magnetic Resonance Spectroscopy Fetus Brain |
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