部芩片联合西药治疗耐多药肺结核17例临床观察

目的 观察部芩片治疗耐多药肺结核患者的临床疗效及机制.方法 将52例耐多药肺结核患者随机分为治疗组17例、微卡组17例、对照组18例,分别给予西药基础治疗加部芩片、西药基础治疗加微卡注射液及西药基础治疗,疗程6个月.观察各组治疗后临床疗效,并检测其治疗前、治疗后2个月、治疗后6个月白细胞介素12(IL-12)、干扰素(IFN-γ)含量.结果 治疗后2个月治疗组、微卡组、对照组的有效率分别为82.35％、52.94％和41.18％.治疗组有效率明显高于对照组(P＜0.05),微卡组和对照组比较差异无统计学意义(P＞0.05).治疗后6个月治疗组、微卡组、对照组的有效率分别为88.24％、82.35％和70.59％,与对照组比较,治疗组和微卡组有效率均明显升高(P＜0.05)；与治疗后2个月比较,治疗后6个月微卡组和对照组有效率均明显升高(P＜0.05),但治疗组差异无统计学意义(P＞0.05).与治疗前比较,治疗后2个月各组IL-12及IFN-γ含量差异均无统计学意义(P＞0.05).与治疗前比较,治疗后6个月治疗组及微卡组IL-12含量明显升高,差异有统计学意义(P＜0.01),各组IFN-γ含量明显升高(P＜0.05 ).治疗后6个月治疗组和微卡组IL-12及IFN-γ含量明显高于对照组(P＜0.05或P＜0.01). 结论 部芩片可以明显提高耐多药肺结核患者的临床疗效；提高耐多药肺结核患者1L-12和IFN-γ含量,达到治疗耐多药肺结核的作用.

Clinical Observation on Buqin Tablet Combined with Western Medicine for 17 Cases of Multidrug-Resistant Tuberculosis

Objective To study the therapeutic effect of Buqin Tablet [Tablet of Baibu(Radix Stemonae) and Huangqin(Radix Scutellariae)] for multidrug-resistant tuberculosis(MDR-TB) and its mechanism.Methods Fifty-two cases of MDR-TB were randomized into treatment group(17 cases),Vaccae group(17 case) and control group(18 cases).All groups were given anti-tuberculosis drugs.Buqin Tablet and Vaccae injection was added respectively in the treatment group and Vaccae group.The treatment lasted for 6 months.The therapeutic effect was observed and the contents of interleukin-12(IL-12) and interferon-α(IFN-α) were detected before and after 2 months and 6 months of treatment.Results After 2 months,the effective rate of the treatment group,Vaccae group and control group was 82.35%(14/17),52.94%(9/17) and 41.18%(7/17) respectively.The effective rate of the treatment group was superior to that of control group(P<0.05).There was no significant difference between the Vaccae group and control group(P>0.05).After 6 months,the effective rate of the treatment group,Vaccae group and control group was 88.24%(15/17),82.35%(14/17) and 70.59%(12/17) respectively.Comparing with the control group,the effective rates of the treatment group and Vaccae group increased significantly(P<0.05).The effective rates of the control group and Vaccae group increased significantly after 6 months of treatment as compared with those after 2 months of treatment(P<0.05).There was no significant difference in the treatment group between different treatment times(P>0.05).After 2 months,the contents of IL-12 and IFN-α increased in the treatment group and Vaccae group without statistical significance(P>0.05).After 6 months,the contents of IL-12 in all the groups increased significantly,especially in the treatment group and Vaccae group(P<0.01).The contents of IFN-α increased significantly in all the groups(P<0.05).Comparing with the control group,the contents of IL-12 and IFN-α increased in the treatment group and Vaccae group after 2 months of treatment,especially after 6 months of treatment(P<0.05 or P<0.01).Comparing with the treatment group,the contents of IL-12 and IFN-α increased in the Vaccae group both after 2 months and 6 months of treatment without statistical significance(P>0.05).Conclusion Buqin Tablet is effective for MDR-TB by increasing the contents of IL-12 and IFN-α.