缺血后处理对急性心肌缺血／再灌注家猪心脏的作用

目的研究缺血后处理对实验家猪心肌梗死范围及血压心率的影响，探讨在体条件下，缺血后处理是否具有缩小家猪缺血心脏的心肌梗死范围。方法采用标准家猪缺血／再灌注模型，在缺血后再灌前，分别给予4个周期和8个周期的短暂再灌注／再缺血作缺血后处理，TTC法确定心肌梗死范围。结果缺血后处理组8-30PostC心肌梗死范围（10．5±0．5）％，缺血后处理组4-30PostC心肌梗死范围及对照组分别为（36．7±3．7）％和（33．5±7．6）％（P〈0．01），8个周期的缺血后处理组家猪心肌梗死面积明显小于对照组以及4个周期组，各组家猪的心率和平均动脉压无明显差异。结论缺血后处理可明显缩小家猪缺血心脏的心肌梗死范围。

Effect of lschemic Postconditioning on Pig Hearts with Acute Myocardial Ischemia and Reperfusion

Objective To explore the possible beneficial effect of ischemic postconditioning in acute ischemic heart and to test whether an effective postconditioning protocol could be identified that can limit infarction size in anesthetized pigs. Methods With a pig model of acute myocardial ischemia perfusion, ischemic postconditioning was achieved by 4 cycles and 8 cycles reperfusion/ischemia before persistent reperfusion. Myocardial infarction size was determined by dual staining with triphenyl tetrazolium chloride and Evan＇ s blue dye. Results In control hearts, 33.5 ± 7.6% of the risk zone infarcted and 36.7 ±3.7 % in the 4 - 30 PostC group （ P =NS）. But there was only 10.5 ±0.5% infarction in the 8 - 30 PostC group （ P 〈0.01 vs. the other two groups）. No significant differences in HR and MBP were observed in groups at the various time points. Conclusion Postconditioning can obviously reduce the infarction area of pigs.