| AMPA受体介导的突触可塑性与药物依赖 |
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| 引用本文： | 何建华,曹君利,曾因明. AMPA受体介导的突触可塑性与药物依赖[J]. 国际麻醉学与复苏杂志, 2007, 28(3): 224-227 |
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| 作者姓名： | 何建华 曹君利 曾因明 |
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| 作者单位： | 1. 210009,南京,江苏省肿瘤医院麻醉科
2. 江苏省麻醉医学研究所,江苏省麻醉学重点实验室 |
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| 摘 要： | 突触可塑性改变是形成药物依赖长期效应的病理基础,兴奋性氨基酸受体在其中起十分重要的作用。近年来的研究表明,多种药物依赖过程与AMPA受体有关。联系药物依赖所致的AMPA受体的变化与神经元的可塑性改变,探讨AMPA受体介导药物依赖的形成机制,可为进一步理解AMPA受体在药物依赖中的作用提供帮助。
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| 关 键 词： | 药物依赖 AMPA受体 突触可塑性 |
AMPA receptor-mediated synaptic plasticity and drug dependence |
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| HE Jian-hua,CAO Jun-li,ZENG Yin-ming. AMPA receptor-mediated synaptic plasticity and drug dependence[J]. international journal of anesthesiology and resuscitation, 2007, 28(3): 224-227 |
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| Authors: | HE Jian-hua CAO Jun-li ZENG Yin-ming |
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| Affiliation: | Department of Anesthesiology, Jiangsu Tumor Hospital, Nanjing 210009, China |
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| Abstract: | Change in synaptic plasticity is the pathologic foundation of drug dependence. AMPA receptor, a member of excitability amino acid receptors, plays an importance role in change of synaptic plasticity. Recent studies have demonstrated that AMPA receptor is involved in the development of drug dependence. This review summarizes the relationship between AMPA receptormediated synaptic plasticity and drug dependence. |
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| Keywords: | drug dependence AMPA receptor synaptic plasticity |
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