Effect of upregulation of AMPA glutamate receptors on cerebral O2 consumption and blood flow in rat |
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| Authors: | Arabinda K. Sinha Aasif H. Mirza Xia Liu Oak Z. Chi Harvey R. Weiss |
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| Affiliation: | Department of Physiology and Biophysics, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 675 Hoes Lane, Piscataway, NJ 08854-5635, USA. |
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| Abstract: | AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate) receptors, in cerebral cortex, underwent upregulation (35% increase) following chronic blockade with a non-competitive AMPA receptor antagonist, GYKI 52466 (1-(aminophenyl)-4-methyl-7, 8-methylenedioxy-5H-2,3-benzodiazepine). Such upregulation did not alter basal cerebrocortical blood flow or O(2) consumption. There was a much higher increase in blood flow and O(2) consumption in the upregulated, agonist (AMPA) stimulated cortices of anesthetized rats. |
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| Keywords: | GYKI 52466 Excitatory amino acid Cerebral blood flow |
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