心肌型脂肪酸结合蛋白对早期诊断心肌损伤的意义探讨

目的 探讨血清心肌型脂肪酸结合蛋白(H-FABP)在早期急性冠脉综合征(ACS)中的临床诊断价值.方法 应用全自动化学发光、生化分析仪检测46例ACS患者入院3～6h及6～12h两个时间段的血清中的H-FABP、肌钙蛋白I(cTnI)、肌红蛋白(MYO)、肌酸激酶同工酶(CK-MB).结果 H-FABP表现出了很好的检测早期(3～6 h)ACS的效果,比MYO、cTnI和CK-MB效果均要好(P＜0.05),单独检测的灵敏度达到了82.61％,而MYO、肌钙蛋白和CK-MB的诊断效果在6～12h段有明显提高.结论 H-FABP具有很好的早期诊断ACS价值,可以将H-FABP作为更早期诊断ACS的心肌损伤标志物应用于临床检测中.

Significance of H-FABP for the diagnosis of myocardial infarction

Objective To evaluate the clinical diagnosis value of H-FABP for early acute coronary syndrome(ACS).Methods Serum H-FABP,cTnI,myoglobin and CK-MB were detected by automatic chemiluminescence and biochemistry analyzer 3～6 and 6～12 hours after the onset of chest pain in 38 patients suspected for ACS.Results H-FABP demonstrated a very good efficacy for the early detection(3～6 hours after the onset of chest pain) of ACS,while the levels of myoglobin,cTnI and CK-MB were sharply increased 6～12 hours after the onset of chest pain.In addition,H-FABP detection sensitivity reached 94.73%.Conclusion H-FABP is of good clinical diagnosis value.It may be use as the marker of early myocardial damage for the early detection of ACS.