乙型肝炎分子流行病学研究进展

乙肝的分子流行病学是运用先进的分子生物学技术研究乙肝流行病学的诸多问题,能够进一步从分子水平阐明乙型肝炎病毒感染的病因、致病过程及发病机制,对于疾病早期诊断、传染性的评估、病情的预测、抗病毒药物疗效的观察、疾病发展进程的监测和乙肝感染自然史的研究等方面均有重要的指导意义.针对近几年乙肝分子流行病学研究的几个热点即乙型肝炎病毒的检测、基因分型、基因系统进化分析、基因变异、基因多态性的研究进展作一回顾.虽然近年来该领域的研究迅速增多,但多数仍处于探索阶段,乙肝病毒感染、清除等诸多机制的研究仍任重而道远.

Study advance in molecular epidemiology of hepatitis B virus

Molecular epidemiology of hepatitis B is the epidemiological study of hepatitis B in molecular biological approach. It can clarify the pathogen, progression and mechanism of hepatitis B virus infection. Molecular epidemiology of hepatitis B is vital important for the early diagnosis, infection assesement, illness prediction, observing antiviral therapies, monitoring disease progression and understanding the natural infectious history of hepatitis B. This review focuses on some hot topics on molecular epidemiology of hepatitis Bin recent years , such as viral detection, genotyping, phylogenetic analysis, gene variation and gene polymorphism, aimed at introducing the present studies briefly. Although the researches on this aspect are increasing quickly , many are in groping status. There are still challenges ahead on the mechanism of viral infection, elimination and so on.