亚临床甲状腺功能异常与心血管疾病的关系

临床研究显示,亚临床甲状腺功能异常与心血管疾病之间存在密切的关系.亚临床甲状腺功能减退通常伴有血脂异常、高凝状态、纤维蛋白溶解活性减低等心血管疾病危险因素,其与动脉粥样硬化、冠心病和心血管死亡的风险显著相关.另一方面,亚临床甲状腺功能亢进与心房颤动发生风险显著相关,但与心血管死亡风险的相关性尚不清楚.对于亚临床甲状腺功能异常进行治疗是否能够带来心血管获益,目前尚无确切结论.

Relationship between subclinical thyroid dysfunction and cardiovascular disease

Clinical studies have shown a dose link between subclinical thyroid dysfunction and car-diovaseular disease. Subclinical hypothyroidism is associated with many cardiometabolic risk factors including dyslipidemia, hypercoagulabale state and decreased fibrinolytic activity ,and therefore contributes to increased risk for atherosclerosis,coronary artery disease and cardiovascular mortality. On the other hand, it has been reported that subclinical hyperthyroidism is associated with atrial fibrillation. However,the association of sub-clinical hyperthyroidism with cardiovascular mortality remains unclear. At present, there is no definite conclu-sion that the treatment of subclinical thyroid dysfunction can bring cardiovascular benefit.